Hemp Agrimony - Provigil (Modafinil) Interaction
Herbal: Hemp Agrimony
Also Known As: Eupatorium cannabinum, Alpenkraut, Cañamazo, Cáñamo Acuático, Cannabine, Chanvre d'Eau, Chanvrin, Donnerkraut, Dostenkraut, Drachenkraut, Dutch Agrimony, Dutch Eupatoire Commune, Eupatorio, Eupatorium, Gemeiner Wasswedost, Herbe de Sainte Cunégonde, Hirshklee, Holy Rope
Drug: Modafinil
Brand names:
Provigil, Sparlon, Alertec
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Modafinil is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Inducers
Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA) which are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46.
- Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20.
Hemp Agrimony Overview
Hemp agrimony (Eupatorium cannabinum) is a flowering plant that belongs to the aster family (Asteraceae). It has hairy, serrated leaves and small, pinkish-purple flowers that bloom in clusters. The plant gets its name from the fact that it has a fibrous stem, which was once used to make hemp rope.
Hemp agrimony has been used medicinally for centuries, and it is believed to have astringent, diuretic, and tonic properties. It is sometimes used to treat digestive disorders, such as diarrhea and dysentery, and it is also used to treat respiratory conditions, such as bronchitis and asthma.
It is important to note that hemp agrimony is not the same as marijuana (Cannabis sativa) and does not contain significant amounts of the psychoactive THC. Additionally, the use of hemp agrimony as a medicine generally isn't recommended as it may contain liver-toxic pyrrolizidine alkaloid (PA) constituents.
Modafinil Overview
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Modafinil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts). Modafinil is also used along with breathing devices or other treatments to prevent excessive sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn't get enough restful sleep). Modafinil is in a class of medications called wakefulness promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.
Hemp Agrimony - More Interactions
Hemp Agrimony interacts with 409 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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