Herb & supplement monograph

Arnica Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines

Arnica Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Arnica drug interaction appears low for most people. None of the listed interactions are rated major, and the single concern behind them rests on lab findings that have not been seen in people.

Interactions deserving the most attention

The one area we watch is anticoagulant and antiplatelet drugs, the blood thinners. Lab studies suggest compounds in arnica flowers could reduce platelet clumping, which in theory could add to a blood thinner's effect on bleeding. That said, this effect has not been reported in humans, and homeopathic arnica preparations are unlikely to cause it at all. Since bleeding risk is closely monitored with these medicines, it still deserves a mention.

What the rest of the list means

Although arnica appears alongside a long list of medications, nearly all of those entries trace back to this one theoretical bleeding concern applied across many individual blood thinners. A large number of listed interactions does not mean each combination is harmful; here, the prediction comes from lab research rather than from problems observed in people taking these medicines together.

Check your medications against Arnica

Based on HelloPharmacist’s Arnica interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Arnica

122 medications have a known interaction with Arnica, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AbciximabReoPro
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Abciximab interaction
AbrocitinibCibinqo
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcenocoumarolSintrom
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Acenocoumarol interaction
Acetaminophen, AspirinGemnisyn
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, IbuprofenCombogesic
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Acetaminophen, Ibuprofen interaction
Acetylsalicylic AcidEntrophen
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Acetylsalicylic Acid interaction Acetylsalicylic Acid drug page: uses, dosage & side effects
Alteplase, TpaActilyse, Activase
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Alteplase, Tpa interaction
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interaction
Aluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interaction Aluminum Hydroxide, Aspirin, Magnesium Hydroxide drug page: uses, dosage & side effects
Anacaulase-bcdbNexoBrid
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Anacaulase-bcdb interaction
AnagrelideAgrylin
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Anagrelide interaction Anagrelide drug page: uses, dosage & side effects
AnisindioneMiradon
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Anisindione interaction
Antithrombin IiiThrombate III
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Antithrombin Iii interaction
ApixabanEliquis
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Apixaban interaction Apixaban drug page: uses, dosage & side effects
ArgatrobanArgatroban
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Argatroban interaction
AspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin interaction Aspirin drug page: uses, dosage & side effects
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interaction
Aspirin, ButalbitalAxotal
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Butalbital interaction
Aspirin, Butalbital, CaffeineFiorinal
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Butalbital, Caffeine interaction Aspirin, Butalbital, Caffeine drug page: uses, dosage & side effects
Aspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction
Aspirin, Butalbital, Caffeine, PhenacetinMarnal
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Butalbital, Caffeine, Phenacetin interaction
Aspirin, CaffeineAnacin
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Caffeine interaction
Aspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Caffeine, Codeine Phosphate interaction
Aspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Caffeine, Dihydrocodeine Bitartrate interaction
Aspirin, Caffeine, Dover's PwdAcedoval, Dovacet
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Caffeine, Dover's Pwd interaction
Aspirin, Caffeine, HydrocodoneDamason-P
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Caffeine, Hydrocodone interaction
Aspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interaction Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin drug page: uses, dosage & side effects
Aspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Caffeine, Orphenadrine interaction
Aspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full Arnica + Aspirin, Caffeine, Phenacetin, Propoxyphene interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Arnica combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Arnica affects

Every type of medication (drug category) Arnica is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Arnica interacts with
Anticoagulant/antiplatelet Drugs
Anticoagulant/Antiplatelet Drugs

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs. Homeopathic arnica preparations are unlikely to have this interaction.
In vitro evidence shows that sesquiterpene lactones in arnica flowers can decrease platelet aggregation. However, this effect has not been reported in humans.

Likelihood Unlikely Evidence D
Monograph

Arnica: Uses, Safety & Side Effects

The bottom line

Arnica is a daisy-family plant used mainly in topical and homeopathic products for bruising, muscle soreness, and pain. The evidence is mixed and mostly weak, and undiluted arnica taken by mouth can be toxic, so it should only be used on unbroken skin or in heavily diluted homeopathic forms. Talk to your pharmacist or doctor before using it.

Arnica
Scientific name
Arnica montana
Family
Asteraceae
Part used
Flowers (and sometimes roots)
Common forms
Topical creams, gels, ointments, oils, and homeopathic tablets or pellets
People commonly use it for
  • Bruising
  • Muscle soreness
  • Joint pain (osteoarthritis)
  • Swelling after injury or surgery
  • Sprains and minor aches

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Topical and homeopathic forms are generally well tolerated, but undiluted arnica should never be swallowed.

PregnancyLikely Unsafe

When used orally or topically; avoid using.

Read the full pregnancy detail
BreastfeedingLikely Unsafe

When used orally or topically; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Arnica is a flowering plant in the daisy (Asteraceae) family. It is best known as Arnica montana, a species that grows in the mountains and meadows of Europe, though related arnica species also grow in North America. It produces bright yellow, daisy-like flowers, and these flowers are the part most often used to make medicine.

People have used arnica for centuries in folk and homeopathic medicine. Today it is most commonly found in topical products such as creams, gels, and ointments applied to the skin, as well as in homeopathic tablets or pellets that contain extremely tiny, diluted amounts of the plant.

How it works

Arnica flowers contain compounds called sesquiterpene lactones (such as helenalin), along with flavonoids and volatile oils. In laboratory and animal research, these compounds appear to have anti-inflammatory effects and may affect how the body responds to injury and swelling.

It is important to know that much of this evidence comes from lab and animal studies, not from large human trials. In homeopathic arnica, the plant is diluted so much that little or no measurable active compound usually remains, so any effect is thought to be very different from that of a topical herbal preparation.

Effectiveness

Does Arnica work?

Evidence overview · 13 uses evaluated
1 Possibly effective 12 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Osteoarthritis
Rating & evidence shown verbatim from Natural Medicines

Topical arnica gel might reduce osteoarthritis pain.

Also studied for 12 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Acne
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical arnica for acne, there is insufficient reliable information about the clinical effects of arnica for this purpose.

Insufficient Reliable Evidence To Rate Bleeding
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral arnica reduces bleeding after surgery.

Insufficient Reliable Evidence To Rate Breast cancer-related hot flashes
Rating & evidence shown verbatim from Natural Medicines

Oral homeopathic arnica has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Bruises
Rating & evidence shown verbatim from Natural Medicines

Most small clinical trials show that neither topical nor oral arnica reduces postoperative bruising.

Insufficient Reliable Evidence To Rate Diabetic retinopathy
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral homeopathic arnica may reduce symptoms of diabetic retinopathy.

Insufficient Reliable Evidence To Rate Dry eye
Rating & evidence shown verbatim from Natural Medicines

It is unclear if eye drops containing arnica extract can improve dry eye in children.

Insufficient Reliable Evidence To Rate Exercise-induced muscle soreness
Rating & evidence shown verbatim from Natural Medicines

Small studies suggest that oral homeopathic arnica does not reduce muscle soreness after exercise. It is unclear if topical arnica is beneficial.

Insufficient Reliable Evidence To Rate Postoperative pain
Rating & evidence shown verbatim from Natural Medicines

Findings related to the use of oral homeopathic arnica are mixed; most studies utilizing a placebo control have yielded negative results.

Insufficient Reliable Evidence To Rate Postoperative recovery
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral homeopathic arnica is beneficial for postoperative recovery.

Insufficient Reliable Evidence To Rate Postoperative swelling
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical arnica reduces swelling after surgery.

Insufficient Reliable Evidence To Rate Stroke
Rating & evidence shown verbatim from Natural Medicines

A small study suggests that oral homeopathic arnica does not improve outcomes after stroke.

Insufficient Reliable Evidence To Rate Tooth extraction
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral homeopathic arnica improves symptoms after tooth extraction in adults or children.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Arnica applied to unbroken skin is generally well tolerated for short periods. Homeopathic arnica, because it is so diluted, is also usually considered low risk. However, undiluted arnica taken by mouth can be poisonous and may cause serious effects on the heart, stomach, and nervous system. It should never be swallowed unless it is a properly prepared homeopathic dilution.

Do not apply arnica to broken skin, open wounds, or near the eyes or mouth. People who are allergic to plants in the daisy family (such as ragweed, marigolds, or chamomile) may react to arnica and should avoid it.

For pregnancy and breastfeeding, there is not enough reliable safety information, so it is best to avoid arnica during these times. Always check with your pharmacist or doctor before using it, especially if you have a health condition or take other medicines.

Side effects

When used on the skin, arnica may cause skin irritation, redness, itching, or allergic rashes (contact dermatitis), especially with long use or in people sensitive to daisy-family plants.

Swallowing undiluted arnica can cause serious problems, including nausea, vomiting, stomach pain, dizziness, irregular heartbeat, and in severe cases damage to the heart or other organs. If someone swallows a non-homeopathic arnica product, seek medical help or contact poison control right away.

Arnica: Reported Adverse Effects

Documented safety reports on Arnica from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, arnica is unsafe and can cause toxicity. When used in homeopathic amounts, arnica seem to be generally well tolerated. Topically, arnica also seems to be generally well tolerated.

Most Common Adverse Effects:

Orally: Bleeding, gastroenteritis, hypertension, muscle paralysis, nausea and vomiting, shortness of breath.

Topically: Contact dermatitis and irritation.

Serious Adverse Effects (Rare):

Orally: Arrhythmia, coma, multi-organ failure, and death.

Reports by condition
Cluster headache Neurologic/CNS

Orally, arnica may cause drowsiness, nervousness, and headache.

Diarrhea Gastrointestinal

Orally, arnica can cause stomach pain, nausea, vomiting, and diarrhea. Homeopathic arnica has been reported to cause dry mouth (30C) and sore tongue (6C). A 24-year-old female presented to the emergency department with palpitations and vomiting 24 hours after ingesting a cup of tea that reportedly contained arnica flowers picked from her local area of mountainous Southern California. The species was not specified in the article and there was no indication by the authors that any testing had been done to confirm the identity of the plant.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Adkison JD, Bauer DW, Chang T. The effect of topical arnica on muscle pain. Ann Pharmacother 2010;44:1579-84.
  3. No authors listed. Final report on the safety assessment of Arnica montana extract and Arnica montana. Int.J.Toxicol. 2001;20:1-11.
  4. Karow JH, Abt HP, Frohling M, and Ackermann H. Efficacy of Arnica montana D4 for healing of wounds after Hallux valgus surgery compared to diclofenac. J Altern Complement Med 2008;14:17-25.
  5. Stevinson C, Devaraj VS, Fountain-Barber A, et al. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. J R Soc Med 2003;96:60-65.
  6. Canders CP, Stanford SR, Chiem AT. A dangerous cup of tea. Wilderness Environ Med. 2014 Mar;25(1):111-2.
Dry skin Dermatologic

Orally, arnica can cause irritation of mucous membranes. Topically, arnica can cause contact itchiness, dry skin, and rash. Oral lesions resulted in a woman who used a mouthwash incorrectly by not following dilution instructions. The mouthwash was 70% alcohol and contained arnica and oil of peppermint.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Adkison JD, Bauer DW, Chang T. The effect of topical arnica on muscle pain. Ann Pharmacother 2010;44:1579-84.
  3. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
Nausea and vomiting Cardiovascular

Orally, arnica can cause tachycardia or a faster heart rate. A 24-year-old female presented to the emergency department with palpitations and vomiting 24 hours after ingesting a cup of tea that reportedly contained arnica flowers picked from her local area of mountainous Southern California. The species was not specified in the article and there was no indication by the authors that any testing had been done to confirm the identity of the plant.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Adkison JD, Bauer DW, Chang T. The effect of topical arnica on muscle pain. Ann Pharmacother 2010;44:1579-84.
  3. No authors listed. Final report on the safety assessment of Arnica montana extract and Arnica montana. Int.J.Toxicol. 2001;20:1-11.
  4. Karow JH, Abt HP, Frohling M, and Ackermann H. Efficacy of Arnica montana D4 for healing of wounds after Hallux valgus surgery compared to diclofenac. J Altern Complement Med 2008;14:17-25.
  5. Canders CP, Stanford SR, Chiem AT. A dangerous cup of tea. Wilderness Environ Med. 2014 Mar;25(1):111-2.
Neuropathic pain Ocular/Otic

In a case report, accidental intake of a large amount of a homeopathic Arnica-30 resulted in acute vision loss due to bilateral toxic optic neuropathy.

  1. Venkatramani DV, Goel S, Ratra V, et al. Toxic optic neuropathy following ingestion of homeopathic medication Arnica-30. Cutan.Ocul.Toxicol. 2013;32:95-97.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established standard dose for arnica. Topical products vary in strength, and homeopathic products are dosed according to the Homeopathic Pharmacopeia of the United States, which uses very high dilutions.

The safest approach is to follow the directions on the product label and use it only as intended. Do not take undiluted arnica by mouth. If you are unsure which product is appropriate or how to use it, ask your pharmacist or doctor for guidance.

Pregnancy & Breastfeeding

Arnica & Pregnancy

Likely Unsafe

When used orally or topically; avoid using.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Arnica & Breastfeeding

Likely Unsafe

When used orally or topically; avoid using.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 10 references that drive our Arnica monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Schroder H, Losche W, Strobach H, et al. Helenalin and 11 alpha, 13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways. Thromb Res 1990;57:839-45.
  4. Adkison JD, Bauer DW, Chang T. The effect of topical arnica on muscle pain. Ann Pharmacother 2010;44:1579-84. PubMed
  5. No authors listed. Final report on the safety assessment of Arnica montana extract and Arnica montana. Int.J.Toxicol. 2001;20:1-11. DOI
  6. Karow JH, Abt HP, Frohling M, and Ackermann H. Efficacy of Arnica montana D4 for healing of wounds after Hallux valgus surgery compared to diclofenac. J Altern Complement Med 2008;14:17-25.
  7. Venkatramani DV, Goel S, Ratra V, et al. Toxic optic neuropathy following ingestion of homeopathic medication Arnica-30. Cutan.Ocul.Toxicol. 2013;32:95-97. PubMed
  8. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
  9. Stevinson C, Devaraj VS, Fountain-Barber A, et al. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. J R Soc Med 2003;96:60-65. PubMed
  10. Canders CP, Stanford SR, Chiem AT. A dangerous cup of tea. Wilderness Environ Med. 2014 Mar;25(1):111-2. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Arnica

45 products in our database contain Arnica. Open any to see its full ingredient list and every drug interaction we check.

Arnica by Herb Pharm Liquid 4 fl. Oz. · 118.4 mL View ingredients & interactions Arnica by L.A. Naturals Liquid 1 fl. Oz. · 30 mL View ingredients & interactions Arnica by Herb Pharm Liquid 1 fl. Oz. · 30 mL View ingredients & interactions Arnica by Herbs Etc. Liquid 8 fl. Oz. · 236 mL View ingredients & interactions Arnica by Herb Pharm Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Arnica 4:1 Extract Powder by TerraVita Premium Collection Powder 1 Ounce(s) View ingredients & interactions Arnica 4:1 Extract Powder by TerraVita Premium Collection Powder 4 Ounce(s) View ingredients & interactions Arnica 450 mg 4:1 Extract by TerraVita Premium Collection Capsule 100 Capsule(s) View ingredients & interactions Arnica Extract by BulkSupplements.com Powder 100 Gram(s) · 3.5 Ounce(s) View ingredients & interactions Arnica Extract by MBi Nutraceuticals Liquid 2 fl. Oz. View ingredients & interactions Arnica Flower by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Arnica Flower 450 mg by TerraVita Premium Collection Capsule 100 Capsule(s) View ingredients & interactions Arnica Flower Powder by TerraVita Premium Collection Powder 1 Ounce(s) View ingredients & interactions Arnica Flower Powder by TerraVita Premium Collection Powder 4 Ounce(s) View ingredients & interactions Arnica Flower Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Arnica Professional Extract by Herb Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Back & Neck Pain by BIOVEA Homeopathics Liquid 1 fl. Oz. · 30 mL View ingredients & interactions BactereXX by Viatrexx Bio Incorporated Liquid 1.7 Ounce(s) · 50 mL View ingredients & interactions CBD+13 by T-Relief Tablet Or Pill 30 Tablet(s) View ingredients & interactions CBD+13 by T-Relief Tablet Or Pill 60 Tablet(s) View ingredients & interactions Herbal Alkalizer by MBi Nutraceuticals Capsule 100 Capsule(s) View ingredients & interactions Menopause by BIOVEA Homeopathics Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Painfree Chocolate Classic Chai Flavor by The Functional Chocolate Company Bar 1.75 Ounce(s) · 50 Gram(s) View ingredients & interactions Taurox 6X Nanotech Nutrients by Allergy Research Group Liquid 0.45 fl. Oz. · 13.5 mL View ingredients & interactions
Pharmacist Counseling Corner

Arnica: Common Questions

What is Arnica used for, and does it work?
People use Arnica for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Arnica for Osteoarthritis. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Arnica interact with prescription medications?
Yes. We list 122 medications with a known interaction with Arnica. Use the checker above to see how Arnica interacts with a specific drug.
How are Arnica interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Arnica with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Arnica interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Arnica used for?
People most often use Arnica on the skin or as a homeopathic product for bruising, muscle soreness, swelling, sprains, and joint pain. The evidence for these uses is limited and mixed.
Is Arnica safe to take by mouth?
Undiluted Arnica is not safe to swallow and can be toxic, affecting the heart and other organs. Only highly diluted homeopathic forms are intended to be taken by mouth.
Can I use Arnica during pregnancy or while breastfeeding?
There isn't enough reliable safety information, so it's best to avoid Arnica during pregnancy and breastfeeding unless your doctor advises otherwise.
Can Arnica cause an allergic reaction?
Yes. Arnica is in the daisy family, and people allergic to plants like ragweed, marigolds, or chamomile may develop skin rashes or other allergic reactions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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