Aspartic Acid Interactions Overview
Check For Interactions With Aspartic Acid
Aspartic Acid
- 2-Aminobutanedioic acid
Aspartic acid, also known as aspartate, is a non-essential amino acid that plays a crucial role in various physiological processes within the body. It functions as a building block in protein synthesis and is a central component of various enzymes. Additionally, aspartic acid plays a key role in the metabolism of nitrogen.
Aspartic acid has been studied for its potential benefits as a dietary supplement. Research indicates that it may aid in cognitive function and memory by increasing the levels of the neurotransmitter acetylcholine, which is critical for memory and learning. Furthermore, aspartic acid has been suggested to enhance athletic performance by increasing energy and endurance through the elevation of creatine levels. It is worth mentioning that aspartame, an artificial sweetener, contains around 40% aspartic acid.
Aspartic acid exists in two forms, D-aspartic acid (D-AA) and L-aspartic acid (L-AA). The structural difference between the two forms is the arrangement of atoms in their molecular structure. D-aspartic acid is more commonly found in dietary supplements for athletics, as it has been studied for its effects on testosterone levels and muscle growth.
Additional Details
Is Aspartic Acid Safe? Any Warnings?
Aspartic acid is considered likely safe when taken orally in amounts found in foods. Short-term use of aspartic acid supplements, such as D-aspartic acid and L-aspartic acid, is also considered possibly safe when used appropriately and in recommended doses.However, there is limited information available on the safety of aspartic acid supplements in children and adolescents, so it is best to avoid using them in amounts exceeding those found in food. In infants, the use of aspartic acid orally is possibly unsafe as it has been shown to cause neuronal necrosis in the hypothalamus in rodents. Until more data is available, pregnant or breastfeeding women are advised to avoid the use of aspartic acid supplements.
How Is Aspartic Acid Thought To Work? What Is the Mechanism of Action?
Aspartic acid is a nonessential amino acid that plays a role in protein synthesis and serves as a building block for various other amino acids. D-aspartic acid, specifically, has functions in the nervous system and reproductive system. Its mechanism of action varies depending on its specific use:1. Antidiabetic Effects: In studies on mice with diabetic kidney disease, supplementation of L-aspartic acid increased circulating levels, reduced albuminuria, decreased markers of oxidative stress, and improved the function of the glomerular endothelial surface layer.
2. Athletic Performance Effects: Some researchers theorize that aspartic acid salts, such as aspartate magnesium and potassium, improve athletic ability. This may be attributed to a reduction in ammonia levels during exercise or the sparing of muscle glycogen. However, evidence from animal and human studies is limited and inconclusive.
3. Hormonal Effects: D-aspartic acid is believed to increase testosterone levels, potentially leading to improvements in muscle mass and exercise performance. While animal studies support this theory, human studies have yielded inconsistent results. The effect of D-aspartic acid on testosterone levels seems to be dose-dependent and varies based on the duration of therapy and the individual's characteristics.
4. Mineral Absorption Effects: Aspartic acid salts, such as copper aspartate, iron aspartate, and magnesium aspartate, are thought to enhance the oral absorption of minerals. There is evidence suggesting that magnesium aspartate is more bioavailable than magnesium oxide in humans.
Pharmacokinetics
Aspartic acid, like other amino acids, is transported into the gut mucosal cells and then enters the systemic blood through a carrier system. If not utilized by the liver, aspartic acid is released into the systemic blood.Supplementary intake of D-aspartic acid has been shown to increase plasma levels. L-aspartic acid is metabolized by the body to synthesize other amino acids such as lysine, threonine, and methionine. Aspartic acid is also a metabolite in the urea cycle and is produced through the breakdown of glucose.
Interaction Overview
There are no known interactions between aspartic acid and drugs, supplements, conditions, or lab tests. However, it is always recommended to consult with a healthcare professional before starting any new supplement or medication.Common Side Effects To Watch For
No adverse effects have been reported with the use of aspartic acid supplements. However, it is important to note that a thorough evaluation of safety outcomes has not been conducted. If any unexpected or concerning side effects occur while taking aspartic acid, it is advisable to consult with a healthcare professional.Are Supplements Standardized?
There is insufficient reliable information available regarding the standardization of aspartic acid supplements. More research is needed in this area to determine if standardization is necessary or beneficial.Note: Aspartic acid should not be confused with aspartame, an artificial sweetener commonly used in various foods and beverages.
Drugs that interact with Aspartic Acid
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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