Bittersweet Nightshade Interactions Overview

Additional Details

Is Bittersweet Nightshade Safe? Are There Any Warnings?

Bittersweet nightshade, particularly the leaves and berries, is considered to be likely unsafe when used orally due to their toxic compounds, including solanine, solanidine, and dulcamarin.

These components can cause various adverse effects, including circulatory and respiratory depression, convulsions, cyanosis, gastrointestinal bleeding, dilated pupils, headache, speech difficulties, vertigo, vomiting, and even death.

The stem of bittersweet nightshade, when used orally or topically, is considered to be possibly safe when used appropriately. However, caution should be exercised during pregnancy and lactation, as well as with children, as there is insufficient reliable information available about the safety of bittersweet nightshade in these populations.

How Is Bittersweet Nightshade Thought To Work? What Is the Mechanism of Action?

Bittersweet nightshade, specifically its stem, contains various components such as steroidal alkaloids (including solasodin), which have anticholinergic effects. The stem is also believed to have astringent, antimicrobial, and mucous membrane-irritating actions. Solasodin, a constituent of bittersweet nightshade, is thought to contribute to its anti-inflammatory properties. However, further research is needed to fully understand the mechanism of action of bittersweet nightshade.

Pharmacokinetics

There is insufficient reliable information available about the pharmacokinetics of bittersweet nightshade. More research is needed to understand how the constituents of bittersweet nightshade are metabolized, absorbed, and eliminated in the body.

Interaction Overview

Currently, there are no known interactions with drugs or supplements associated with bittersweet nightshade. However, caution should always be exercised when combining any medications or supplements with herbal products.

Common Side Effects To Watch For

When used orally, the leaves and berries of bittersweet nightshade can cause toxicity and various adverse effects, as mentioned above. There is limited information available about the adverse effects specifically related to the stem of bittersweet nightshade when used in medicinal amounts.

Standardization & Formulation

There is insufficient reliable information available about the standardization of bittersweet nightshade. The potency and composition of different preparations of bittersweet nightshade may vary. It is important to follow product labeling and consult with healthcare professionals to ensure the use of standardized and appropriate formulations.

What Is Bittersweet Nightshade Typically Used For?

The effectiveness of bittersweet nightshade for specific uses is still unclear due to insufficient reliable evidence. More research is needed to determine the potential therapeutic benefits of bittersweet nightshade. However, traditional uses include the utilization of the stem for its anti-inflammatory, antirheumatic, diuretic, narcotic, and sedative properties. It is important to note that the leaves and berries of bittersweet nightshade are toxic and should not be used orally. 

Drugs that interact with Bittersweet Nightshade