Chlorophyllin Interactions Overview

Additional Details

Is Chlorophyllin Safe? Are There Any Warnings?

Chlorophyllin, a semi-synthetic derivative of chlorophyll, is generally considered safe when consumed in the amounts found in foods. It is permitted for use as a coloring agent in limited quantities in foods. When used orally and for short-term periods, chlorophyllin is possibly safe. However, there is insufficient reliable information about its long-term oral use. It is important to note that chlorophyllin supplements may contain copper, and high levels of copper consumption can lead to serious adverse effects. The safety of chlorophyllin when used topically is also unclear. It is advised to exercise caution and consult with a healthcare professional.

For children, there is insufficient reliable information about the safety of chlorophyllin. The copper content in chlorophyllin supplements should be considered, and caution is advised.

During pregnancy and lactation, insufficient reliable information is available, so it is recommended to avoid using chlorophyllin.

Common Side Effects to Watch For

When used orally for up to 3 months, chlorophyllin is generally well tolerated. However, a comprehensive evaluation of safety outcomes has not been conducted. There is insufficient reliable information about the safety of chlorophyllin when used topically.

Are Supplements Standardized?

There is insufficient reliable information available about the standardization of chlorophyllin.

What Is Chlorophyllin Typically Used For?

Chlorophyllin is possibly ineffective or insufficiently studied for several conditions, including reducing urinary odor, improving acne, reducing body odor, preventing cancer, treating constipation, reducing fecal odor, reducing flatulence, managing leukopenia, promoting wound healing, and reducing wrinkles. More evidence is needed to determine its effectiveness for these uses.

How Is Chlorophyllin Thought to Work? What Is the Mechanism of Action?

Chlorophyllin is a semi-synthetic derivative of chlorophyll, where magnesium is replaced with another cation such as copper, iron, or zinc. It is water-soluble and has improved stability compared to chlorophyll. The mechanism of action of chlorophyllin includes the following:

• Anti-cancer effects: In vitro studies suggest that chlorophyllin exhibits antimutagenic activity by reducing carcinogen DNA-binding and chromosome damage. It may also reduce carcinogen-induced cell transformation. Chlorophyllin has been investigated for its potential to reduce the absorption and bioavailability of aflatoxin, a fungal toxin associated with hepatocellular carcinoma.
• Anti-inflammatory effects: Chlorophyllin has shown activity against inflammation induced by Propionibacterium acnes and inflammatory bowel disease in experimental models.
• Antioxidant effects: Animal research indicates that chlorophyllin exhibits antioxidant activity by reducing reactive oxygen species and enhancing the activity of antioxidant enzymes.
• Hepatic effects: Chlorophyllin has been studied for its potential to attenuate liver steatosis, dyslipidemia, insulin resistance, and weight gain in a mouse model of nonalcoholic fatty liver disease (NAFLD) when added to a high-fat diet.
• Odor reduction effects: Chlorophyllin has been associated with a reduction in various bodily odors, although the mechanism of this effect is unclear and requires further research.

Pharmacokinetics

There is limited research available regarding the pharmacokinetics of chlorophyllin. Oral administration of chlorophyllin resulted in the absorption of copper chlorin E4 ethyl ester, but more research is needed to understand its absorption, distribution, metabolism, and elimination in the body.

Interaction Overview (See Full List At Bottom Of Page)

Chlorophyllin may interact with photosensitizing drugs and photosensitizing herbs, potentially having additive effects. Caution is advised when combining chlorophyllin with these substances. No significant interactions with other drugs or supplements are currently known.

Drugs that interact with Chlorophyllin