Cordyceps Interactions Overview

Additional Details

Is Cordyceps Safe? Are There Any Warnings?

The commercially propagated forms of cordyceps typically contain only the mycelia and not the fruiting body or mushroom. This information focuses on the safety of artificially propagated cordyceps mycelial cells. When used orally and appropriately, cordyceps is considered possibly safe. It has been used with apparent safety in doses of 3-6 grams daily for up to 1 year. However, there is insufficient reliable information available regarding the use of cordyceps during pregnancy and lactation, so it is advisable to avoid using it during these periods.

How Is Cordyceps Thought to Work? What Is the Mechanism of Action?

Cordyceps is a fungus, and for commercial and experimental purposes, the mycelial cells of cordyceps are propagated in a laboratory setting. Cordyceps contains various active constituents, including polysaccharides, adenosine, cordycepin, cordycepic acid, and ergosterol. The propagated mycelial cells are believed to have similar constituents to those found in the wild fungus. Cordyceps has shown potential in various areas, including anticancer effects, cardiovascular effects, endocrine effects, and immunologic effects. It may enhance immune response, reduce tumor size, inhibit platelet aggregation, regulate blood glucose levels, and impact immunologic activity. However, more research is needed to fully understand the mechanisms of action of cordyceps.

Pharmacokinetics

Insufficient reliable information is available about the pharmacokinetics of cordyceps. Further studies are required to gain a better understanding of its pharmacokinetic properties.

Interaction Overview (See Full List At Bottom Of Page)

Cordyceps may interact with certain drugs, including anticoagulant/antiplatelet drugs, immunosuppressants, and testosterone. It is important to exercise caution and consult with a healthcare professional if you are taking any of these medications.

Common Side Effects to Watch For

When used orally for up to 1 year, cordyceps is generally well tolerated. The most common adverse effects include abdominal discomfort, constipation, and diarrhea. It is important to monitor for any gastrointestinal, hematologic, hepatic, or renal side effects and consult a healthcare professional if any concerns arise.

Are Supplements Standardized?

There is insufficient reliable information available about the standardization of cordyceps supplements. It is advisable to choose products from reputable manufacturers that adhere to good manufacturing practices.

What Is Cordyceps Typically Used For?

Cordyceps has been investigated for various uses; however, the evidence supporting its effectiveness is limited. Oral cordyceps has been evaluated for conditions such as athletic performance, arrhythmia, asthma, chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), contrast-induced nephropathy, cough, fatigue, hepatitis B, hypercholesterolemia, kidney failure, kidney transplant, sexual dysfunction, and tinnitus. While some preliminary studies suggest potential benefits in certain areas, more evidence is needed to establish the true efficacy of cordyceps for these uses.

Dosing & Administration

Adult: Cordyceps has typically been used orally in doses of 3-6 grams daily for up to 1 year. Most studies have utilized mycelial fermentation products of cordyceps. Please refer to the Effectiveness section for condition-specific information. It is recommended to consult with a healthcare professional for appropriate dosing guidance.

Drugs that interact with Cordyceps