Dandelion Interactions Overview

Additional Details

Is Dandelion Safe? Are There Any Warnings?

Dandelion is a perennial herb that has been traditionally used for various health purposes. When used in normal food amounts, dandelion is generally considered safe. It has been given Generally Recognized as Safe (GRAS) status in the United States. However, caution should be exercised when using dandelion in medicinal amounts. It is important to note that there is insufficient reliable information available about the use of dandelion during pregnancy and lactation, so it is advised to avoid using larger amounts than those typically found in foods during these periods.

How Is Dandelion Thought to Work? What Is the Mechanism of Action?

Dandelion contains various compounds in its leaves, flowers, and root that contribute to its potential effects. Here's a breakdown of its mechanism of action:

• Anti-inflammatory effects: Dandelion has shown preliminary evidence of anti-inflammatory effects. Compounds found in dandelion may inhibit the production of inflammatory substances in the body, potentially reducing inflammation.
• Antineoplastic effects: Dandelion extracts have demonstrated antioxidant and cytotoxic effects on cancer cells in preliminary research. These extracts may have the potential to inhibit the growth of cancer cells.
• Antioxidant effects: Dandelion flower extract has been shown to possess antioxidant properties in laboratory studies. These antioxidant effects may contribute to the overall potential benefits of dandelion.
• Antiurolithiatic effects: Animal research suggests that dandelion may have antiurolithiatic effects, potentially reducing crystal deposition in the urinary tract. These effects may be attributed to specific constituents found in dandelion.
• Antiviral effects: Laboratory research indicates that dandelion extracts may possess antiviral properties, particularly against influenza virus and human immunodeficiency virus-1 (HIV-1).
• Diuretic effects: Dandelion has been found to have diuretic activity in animal studies. This may be due to certain compounds, such as sesquiterpene lactones, present in dandelion.
• Gastrointestinal effects: Dandelion is traditionally used to stimulate appetite, bile production, and bile flow. It may also have a beneficial effect on intestinal bacteria and promote their growth.
• Hypoglycemic effects: In vitro evidence suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and could potentially increase insulin secretion.
• Immune effects: Preliminary research suggests that dandelion might enhance immune system function, although more studies are needed to fully understand its impact.

Pharmacokinetics

There is insufficient reliable information available about the pharmacokinetics of dandelion. Further research is needed to understand how dandelion is absorbed, metabolized, and eliminated from the body.

Interaction Overview

Dandelion may interact with certain drugs and supplements, potentially leading to altered effects or risks. Here are some interactions to be cautious about:

• Anticoagulant/antiplatelet drugs: Taking dandelion root alongside anticoagulant or antiplatelet drugs may increase the risk of bruising and bleeding.
• Antidiabetes drugs: Dandelion may increase the risk of hypoglycemia when used in combination with antidiabetes drugs.
• Cytochrome P450 1A2 (CYP1A2) substrates: Dandelion may increase the levels of drugs metabolized by the CYP1A2 enzyme.
• Glucuronidated drugs: Dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
• Lithium: Dandelion may affect the excretion and levels of lithium in the body.
• Potassium-sparing diuretics: There is a possibility that dandelion may increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
• Quinolone antibiotics: Dandelion might lower the levels of certain quinolone antibiotics.

It's important to be aware of these potential interactions and consult with a healthcare professional before using dandelion, especially if you are taking any medications or supplements.

Common Side Effects To Watch For

When using dandelion, common side effects to watch for include diarrhea, heartburn, stomach discomfort, and, in sensitive individuals, dermatitis when applied topically. Serious adverse effects are rare but may include anaphylaxis in sensitive individuals. If any of these side effects occur or worsen, it is advisable to discontinue use and seek medical attention.

Are Supplements Standardized?

There is insufficient reliable information available about the standardization of dandelion supplements. It is important to choose reputable brands and consult product labels for information on quality and standardized content.

Drugs that interact with Dandelion