Dhea Interactions Overview

Check For Interactions With Dhea

Dhea

Also known as
  • 3b-Hydroxy-Androst-5-Ene-17-One
  • 3BetaHydroxy-Androst-5-Ene-17-One
  • Androstenolone
  • Déhydroépiandrostérone
  • DHEA-S
  • GL701
  • Prasterone
Dhea Dehydroepiandrosterone (DHEA) is a natural (i.e., endogenous) hormone produced by the adrenal gland and is among the most abundant steroid hormones in the human body. It is a precursor to the hormones testosterone and estrogen, and it is thought to have various effects on the body. DHEA levels naturally decline with age. It is a popular over the counter supplement that is purported to have a variety of health benefits, including increasing muscle mass, improving cognitive function, improving mood and reducing the risk of heart disease and diabetes. The scientific evidence supporting the use of DHEA for these purposes is limited and mixed. Additionally, it could potentially interact with several different medications so if you are considering taking DHEA supplements, it is important to speak with a healthcare professional. DHEA should not be confused with other supplements containing the letters 'DHEA'. 7-alpha-hydroxy-DHEA, 7-beta-hydroxy-DHEA, and 7-keto-DHEA, all contain DHEA as the parent compound with additional structures attached.
There are 731 drugs known to interact with Dhea

Additional Details

Is DHEA Safe? Are There Any Warnings?

DHEA is considered possibly safe when used orally, intravaginally, or topically in appropriate doses and for short-term periods. Studies have shown that doses of around 50 mg per day have been well-tolerated in most cases for up to 6 months. Some studies have even used oral DHEA safely for up to 24 months. However, caution is advised when using high doses or using it long-term as it may increase the risk of hormone-sensitive cancers like prostate or breast cancer. There is insufficient information available about the safety of using DHEA intravenously or intramuscularly. For pregnant and lactating individuals, oral use of DHEA is possibly unsafe, as it can cause higher than normal androgen levels that may affect pregnancy or the nursing infant.

How Is DHEA Thought To Work? What Is the Mechanism of Action?

DHEA, or dehydroepiandrosterone, is a hormone produced naturally by the body. It is converted into other hormones like estrogen and testosterone. DHEA is believed to work by interacting with certain receptors in the body, affecting various physiological processes. It can influence mood, energy levels, muscle mass, and even aging. However, the precise mechanisms are still not entirely clear, and more research is needed to fully understand how it works.

Pharmacokinetics

When taken orally, DHEA has low bioavailability, meaning only a small amount reaches the bloodstream. After ingestion, DHEA is processed by the body's metabolism. The specific pathways of absorption and metabolism are not yet fully understood, but this low bioavailability might be why higher doses are sometimes used. More research is required to unravel the complete pharmacokinetic profile of DHEA.

Interaction Overview (See Below For Full List)

DHEA may interact with various drugs and supplements, including anticoagulants, antidepressants, estrogen therapy, and others. These interactions can influence the effectiveness of medications or supplements and may cause adverse effects. If you are taking any medications or have existing medical conditions, it is essential to consult with a healthcare professional before using DHEA.

Common Side Effects To Watch For

When used orally or topically, DHEA is generally well-tolerated, but some common side effects include acne, headache, insomnia, mood changes, and nausea. In females, DHEA may lead to masculinization symptoms like deepening of the voice and unnatural hair growth, while males may experience breast tenderness and testicular issues. Serious adverse effects are rare, but long-term oral use of DHEA may potentially increase the risk of cardiovascular events and certain types of cancer.

Are Supplements Standardized?

The accuracy of dehydroepiandrosterone (DHEA) content in dietary supplements varies significantly. Some products meet their label claims, while others have discrepancies. It's crucial to choose supplements from reputable manufacturers to ensure you get the expected dosage and quality. DHEA supplements are derived synthetically from natural sources like soy and wild yam, but consuming soy or wild yam directly will not have the same effect on DHEA levels in the human body. To avoid confusion, avoid products labeled as "natural DHEA" from soy or wild yam and opt for standardized supplements.

What Is DHEA Used For?

  • Anti-aging: DHEA is believed to play a role in the aging process, and some people use it as a dietary supplement to slow down age-related changes. It is thought to help improve skin health, reduce wrinkles, and enhance overall vitality.
  • Weight management: DHEA is sometimes used as a supplement to aid in weight loss or weight maintenance. It may help increase metabolism and reduce body fat, but more research is needed to fully understand its effects on weight management.
  • Libido enhancement: DHEA supplementation is often sought after for its potential to improve libido and sexual function. It may increase testosterone levels, which can positively impact sexual desire and performance.
  • Depression and mood disorders: DHEA has been studied for its potential antidepressant effects. Some research suggests that it may help alleviate symptoms of depression and improve mood, particularly in individuals with low DHEA levels.
  • Bone health: DHEA is involved in the production of sex hormones, which play a role in maintaining bone density. Some studies indicate that DHEA supplementation may help improve bone mineral density and reduce the risk of osteoporosis.
  • Adrenal insufficiency: In cases of adrenal insufficiency, where the adrenal glands do not produce sufficient hormones, DHEA supplementation may be used to restore hormone levels. It can help address symptoms such as fatigue, muscle weakness, and low libido.

Drugs that interact with Dhea

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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