Diindolylmethane Interactions Overview
Check For Interactions With Diindolylmethane
Diindolylmethane
- DIM
Diindolylmethane (DIM) is a compound found in cruciferous vegetables such as broccoli, cabbage, and kale. It is formed during the digestion of indole-3-carbinol, another compound found in these vegetables. DIM has been studied for its potential health benefits, including improved hormone balance and reduced risk of certain cancers. DIM (Diindolylmethane) supplements are often marketed as a natural way to support hormone balance, specifically estrogen imbalances, and as a 'detoxifying agent'. Supplements with DIM are often paired with Bioperine to improve absorption.
Does DIM Have Any Drug Interactions?
There are some drug classes that DIM may interact with, and these include:
- Drugs that are metabolized by the liver enzyme CYP1A2: DIM may induce this enzyme, increasing the metabolism of certain drugs.
- Diuretics: DIM may reduce sodium levels, and could have additive effects with diuretics that increase sodium loss.
- Estrogen: DIM may have both estrogenic and anti-estrogen effects.
Each of these interactions is presented in detail on individual drug-herbal interaction pages.
Does DIM Have Any Side Effects?
DIM is generally considered safe when taken in appropriate doses, with few reported side effects.
However, some individuals may experience mild gastrointestinal discomfort, headaches, or dizziness when taking DIM.
Additionally, there is some concern that high doses of DIM may interfere with hormone replacement therapy (HRT) by altering estrogen levels in the body (as noted in our drug interaction pages).
Are DIM Supplements Standardized?
DIM supplements are typically standardized to contain a specific amount of the active compound (generally, at least 25% diindolylmethane).
The most common standardization is 100-200 mg per capsule or tablet, although higher doses of up to 600 mg per day have been studied.
It is important to choose a DIM supplement that is standardized to contain a consistent amount of the active compound and that is manufactured by a reputable company.
Many DIM supplements contain Bioperine, a black pepper extract, to improve absorption.
Drugs that interact with Diindolylmethane
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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