Eleuthero Interactions Overview

Check For Interactions With Eleuthero

Eleuthero

Also known as
  • Eleutherococcus senticosus
  • Acanthopanax Obovatus
  • Ciwujia Root
  • Devil's Bush
  • Eleuthero Ginseng
  • Eleuthero Root
  • Eleutherococci Radix
  • Ginseng Siberiano
  • North Wu Jia Pi
  • Shigoka
  • Siberian Eleuthero
  • Siberian Ginseng
  • Eleuthero
  • Touch-Me-Not
  • Wild Pepper
  • Wu-jia
Eleuthero Eleuthero (Eleutherococcus senticosus) is a plant native to Asia and a member of the Araliaceae family. It is also commonly known as 'Siberian ginseng' or 'eleuthero root'. The root of the plant is used in traditional medicine for its purported ability to improve physical and mental performance, boost the immune system, and reduce fatigue. It is also claimed to have anti-inflammatory and antioxidant properties. Eleuthero is often referred to as an 'adaptogen'. Adaptogens are believed to help the body resist stress. It is important to note that although eleuthero is known as 'Siberian ginseng', it is not related to Panax ginseng.
There are 1084 drugs known to interact with Eleuthero

Additional Details

Is Eleuthero Safe? Are There Any Warnings?

Eleuthero is generally considered safe when used orally and appropriately in the short-term. However, there is insufficient reliable information available about its safety when used long-term. 

How Is Eleuthero Thought To Work? What Is the Mechanism of Action?

Eleuthero is believed to work as an adaptogen, helping the body resist physiological and psychological stress. It is theorized that eleuthero modulates the hypothalamic pituitary adrenal (HPA) axis, which may decrease nitric oxide (NO) and cortisol levels. This modulation can help balance immunity, hormones, and stress responses.

Eleuthero also exhibits antioxidant, anti-inflammatory, cardioprotective, immunomodulatory, and neuroprotective effects. Its bioactive components, including isofraxidin, syringin, and eleutherosides, are thought to play a significant role in these mechanisms of action.

Pharmacokinetics

Absorption: Animal studies have shown that injection of eleuthero resulted in the detection of its active constituents, eleutherosides B and E, in the blood. Distribution: Eleutherosides B and E have been found in various organs, including the liver, kidney, spleen, and heart, after intravenous administration.

Interaction Overview (See Bottom of Page For Full List)

Eleuthero may interact with anticoagulant/antiplatelet drugs, antidiabetic drugs, cytochrome P450 substrates, digoxin, immunosuppressants, organic anion-transporting polypeptide substrates, and P-glycoprotein substrates.

It may also interact with certain herbs and supplements, as well as worsen cardiovascular conditions and hormone-sensitive cancers/conditions. Patients taking these medications or with these conditions should exercise caution and consult their healthcare provider before using eleuthero.

Common Side Effects To Watch For

The oral use of eleuthero may cause side effects such as diarrhea, dyspepsia, gastrointestinal upset, headache, nausea, and urticaria.

Are Supplements Standardized?

Eleuthero supplements may be standardized to contain certain active constituents, such as eleutheroside B and eleutheroside E.

However, the quantities of these constituents may vary depending on how the plants are grown, harvested, and processed. It is advisable to look for products that provide accurate information on standardization and quality assurance.

What Is Eleuthero Typically Used For [as a dietary supplement]?

Eleuthero is commonly used as a dietary supplement for the following purposes:

  • Boosting physical and mental performance
  • Enhancing resistance to stress
  • Improving quality of life
  • Managing symptoms of chronic fatigue syndrome
  • Supporting immune function
  • Reducing the severity and frequency of genital herpes outbreaks

Please note that while some of these uses have some evidence supporting their effectiveness, others have insufficient reliable evidence. It is always a good idea to consult with a healthcare professional before using eleuthero or any other dietary supplement.

Drugs that interact with Eleuthero

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC