L-ornithine-l-aspartate Interactions Overview
Check For Interactions With L-ornithine-l-aspartate
L-ornithine-l-aspartate
L-ornithine-L-aspartate is a combination of the amino acids L-ornithine and L-aspartate. It is often used as a dietary supplement and is believed to support liver function. The compound is thought to help in the detoxification process by promoting the elimination of ammonia, a waste product in the body. Some studies suggest that L-ornithine-L-aspartate may be beneficial in liver-related conditions, such as cirrhosis, by reducing ammonia levels and improving overall liver function.
Additional Details
Is L-ornithine-L-aspartate Safe? Are There Any Warnings?
L-ornithine-L-aspartate is generally considered safe when taken orally in doses up to 18 grams daily for six months or intravenously up to 40 grams daily for 35 days. However, caution is advised during pregnancy and lactation due to insufficient information.
How Does L-ornithine-L-aspartate Work? What is the Mechanism of Action?
L-ornithine-L-aspartate, a combination of ornithine and aspartic acid, acts as a source for these amino acids in the body. It aids in detoxifying ammonia, a process crucial for liver health. Specifically, it reduces central fatigue during exercise by preventing an increase in systemic ammonia levels. Moreover, it supports the urea cycle enzyme system and promotes the synthesis of glutamine, reducing ammonia levels in the blood.
Pharmacokinetics
When taken orally, L-ornithine-L-aspartate increases levels of aspartic acid and ornithine in the blood, reaching maximum levels about one hour after intake. In the body, it breaks down into ornithine and aspartic acid, both essential for the urea cycle and glutamine synthesis.
Interaction Overview
No known interactions with drugs, supplements, conditions, or lab tests have been reported for L-ornithine-L-aspartate. Overdose information is insufficiently documented.
Common Side Effects to Watch For
Generally well-tolerated, common adverse effects include cough, muscle cramps, and nausea when administered intravenously. No significant gastrointestinal, musculoskeletal, or pulmonary/respiratory issues are commonly associated with its use.
Are Supplements Standardized?
Forms of L-ornithine-L-aspartate are available both orally and intravenously. The oral product, such as Hepa-Merz Granulate, is commonly used in clinical trials.
What Is L-ornithine-L-aspartate Typically Used For?
L-ornithine-L-aspartate has shown effectiveness in treating hepatic encephalopathy, improving symptoms in cirrhosis patients. Its use in conditions like athletic performance, cachexia, cirrhosis complications, and wound healing requires further research for conclusive evidence.
Drugs that interact with L-ornithine-l-aspartate
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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