Manganese Interactions Overview

Additional Details

Is Manganese Safe? Are There Any Warnings?

Manganese is generally safe when taken orally in appropriate doses, staying below the recommended limits. However, excessive oral doses or long-term parenteral use can lead to significant adverse effects. Inhaling moderate doses of manganese over the long term is also a potential safety concern.

How Does Manganese Work? What is the Mechanism of Action?

Manganese is a vital nutrient serving as a cofactor in various metabolic and enzymatic reactions within the body. It plays a role in amino acid, cholesterol, and carbohydrate metabolism, immune response, and glucose regulation. It's found in several foods like nuts, legumes, seeds, and green vegetables. However, excessive levels, especially in the brain, can interfere with mitochondrial function and neurotransmission, possibly causing Parkinson-like symptoms and affecting bone health.

Pharmacokinetics

Manganese is typically absorbed at less than 5% from dietary sources, and absorption can vary between genders. Once absorbed, it accumulates in tissues, particularly in bones, where it can persist for many years. The liver primarily clears manganese from the body.

Interaction Overview (See Full List Below)

Manganese can interact with certain medications and supplements, affecting their absorption and efficacy. Caution should be exercised when combining manganese with antipsychotic drugs, quinolone antibiotics, or tetracycline antibiotics. Interaction with calcium, IP-6, iron, and zinc supplements may also influence manganese absorption.

Common Side Effects To Watch For

Ordinarily, manganese is well-tolerated, but high doses might cause neurotoxicity, resulting in Parkinson-like symptoms. However, such severe adverse effects are rare.

What Is Manganese Typically Used For?

Manganese is essential for preventing and treating manganese deficiency. However, its effectiveness in treating conditions like allergic rhinitis, chronic obstructive pulmonary disease, obesity, osteoarthritis, osteoporosis, premenstrual syndrome, and wound healing when used alone is not clearly established and requires further research.

Dosing & Administration

The typical dosing of manganese varies depending on age and condition. It's usually recommended to take manganese in combination with other ingredients. For adults, adequate intake levels are defined, and it's best absorbed with milk and fat-containing foods.

Overdose

Overdose of manganese can lead to symptoms of neurotoxicity, especially when taken in excessive doses for a prolonged period. Treatment for manganese overdose is not well-documented, emphasizing the importance of using manganese within recommended limits.

Types of Dietary Supplement Manganese

Manganese supplements are available in various forms, including:

• Manganese Chloride: A form of manganese commonly used in dietary supplements.
• Manganese Sulfate: Another common form of manganese found in supplements.
• Manganese Ascorbate: Manganese combined with ascorbic acid (Vitamin C) to enhance absorption.

Drugs that interact with Manganese