Phosphatidylserine Interactions Overview

Additional Details

Is Phosphatidylserine Safe? Are There Any Warnings?

Phosphatidylserine, a natural phospholipid found in the body and brain, is generally considered safe when taken orally in appropriate doses. Most concerns regarding safety were related to supplements derived from bovine cortex, but nowadays, the majority of supplements are sourced from soy or cabbage to eliminate any risk of contamination. It's important to stick to recommended doses and consult with a healthcare professional, especially during pregnancy and lactation, due to insufficient information about its safety in these circumstances.

How Does Phosphatidylserine Work? What Is the Mechanism of Action?

Phosphatidylserine is a fat-soluble phospholipid crucial for brain function, forming a significant part of the brain's cell membranes. It plays a vital role in various neuronal activities like maintaining cell environment, signaling, and communication between cells. While the body can produce phosphatidylserine, dietary sources are also important. Studies suggest that it may help combat stress, support cardiovascular health, aid in muscle-related issues, and potentially improve memory and cognitive function. The exact mechanisms are still being researched.

Pharmacokinetics

Phosphatidylserine is efficiently absorbed by the body, reaching the bloodstream within 30 minutes after oral intake. Research in animals indicates that it accumulates in the brain and liver upon ingestion, highlighting its distribution within the body.

Interaction Overview

Phosphatidylserine might interact with anticholinergic and cholinergic drugs, potentially affecting their effectiveness. Caution is advised when using these substances in conjunction with phosphatidylserine.

Common Side Effects to Watch For

Orally administered phosphatidylserine is generally well-tolerated, with common side effects being flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Are Supplements Standardized?

Phosphatidylserine supplements are now primarily derived from soy or cabbage to mitigate any concerns about contamination from animals. This practice has been established to ensure the safety and quality of the supplements.

What Is Phosphatidylserine Typically Used For?

Phosphatidylserine shows promise in supporting age-related cognitive decline and potentially improving cognitive function in individuals with Alzheimer's disease. However, more research is needed to determine its effectiveness for athletic performance, ADHD, depression, and other conditions.

Drugs that interact with Phosphatidylserine