Herb & supplement monograph

Pomegranate Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Pomegranate interacts with medications. The heart of this page is the interaction list — every drug Pomegranate is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Pomegranate is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Pomegranate Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Pomegranate drug interaction appears low for most people. None of the listed interactions are rated major, most are minor, and even the moderate ones rest on theoretical or limited evidence rather than well-controlled human studies.

Interactions deserving the most attention

The interactions worth the most awareness involve closely monitored medicines. Pomegranate juice can modestly lower blood pressure, so it could add to the effect of blood pressure medications, including ACE inhibitors. Single case reports link pomegranate juice to changes in bleeding measures with warfarin and to muscle breakdown in one person taking rosuvastatin, though neither is proven. Because these drugs have narrow safety margins, any shift in their effect matters more than it would for other medicines.

What the rest of the list means

The long list of interacting medications mostly reflects theory, not documented harm. Pomegranate may affect enzymes the body uses to clear certain drugs, so hundreds of medications get flagged automatically. In human studies, several of these predicted effects either did not appear or were too small to matter clinically.

Check your medications against Pomegranate

Based on HelloPharmacist’s Pomegranate interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Pomegranate

922 medications have a known interaction with Pomegranate, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcebutololRhotral, Sectral
Moderate Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Read the full Pomegranate + Acebutolol interaction Acebutolol drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Chlorzoxazone, Codeine interaction
Acetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Codeine interaction
Acetaminophen, Codeine, DoxylamineMersyndol
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Codeine, Doxylamine interaction
Acetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Codeine, Methocarbamol interaction
Acetaminophen, DextromethorphanTylenol Cough Ex Strength
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Dextromethorphan interaction
Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction
Acetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Hydrocodone interaction
Acetaminophen, MeperidineDemerol APAP
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Meperidine interaction
Acetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Oxycodone interaction
Acetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Read the full Pomegranate + Acetaminophen, Propoxyphene interaction
AcetazolamideAk-Zol, Diamox
Moderate Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Read the full Pomegranate + Acetazolamide interaction Acetazolamide drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Pomegranate combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Pomegranate affects

Every type of medication (drug category) Pomegranate is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 9 drug categories Pomegranate interacts with
Ace Inhibitors (aceis)Antihypertensive DrugsCytochrome P450 2d6 (cyp2d6) SubstratesRosuvastatin (crestor)Warfarin (coumadin)Carbamazepine (tegretol)Cytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesTolbutamide (orinase)
Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D
Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B
Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D
Monograph

Pomegranate: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evidence is still limited and not strong enough to call it a proven treatment. As a food it is generally safe, but talk to your pharmacist or doctor before using concentrated extracts, especially if you are pregnant, breastfeeding, or take medications.

Pomegranate
Scientific name
Punica granatum
Family
Lythraceae
Part used
Fruit, juice, seeds (arils), peel/rind, flower, and leaf
Common forms
Fresh fruit, juice, extract capsules, powder, tea, and topical products
People commonly use it for
  • Heart and blood vessel health
  • Antioxidant support
  • High blood pressure
  • Inflammation
  • Digestive upset
  • Skin health

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLikely safe

Pomegranate fruit and juice are generally safe for most people as food.

PregnancyPossibly Safe

When the fruit or fruit juice is consumed orally and appropriately. There is insufficient reliable information available regarding the safety of using...

Read the full pregnancy detail
BreastfeedingPossibly Safe

When the fruit or fruit juice is consumed orally and appropriately. There is insufficient reliable information available regarding the safety of using...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Pomegranate (Punica granatum) is a fruit-bearing shrub or small tree that is native to the Middle East and South Asia and is now grown in warm regions around the world. It is best known for its bright red, juicy seeds (called arils), which have a tart, slightly sweet flavor.

People eat the fresh fruit, drink the juice, and use various parts of the plant — including the peel, flowers, and leaves — in traditional medicine. Today pomegranate is also sold as juice concentrates, dried powders, and extract capsules that are often standardized for antioxidant compounds.

It is popular partly because it is a rich source of antioxidants, vitamins, and minerals. In traditional systems of medicine, it has long been used for digestive complaints and for its supposed anti-inflammatory effects.

How it works

Pomegranate contains a range of plant compounds, including polyphenols such as punicalagins and ellagic acid, along with anthocyanins (the pigments that give the fruit its red color) and tannins. These are thought to act as antioxidants, helping to neutralize unstable molecules called free radicals.

Researchers believe these compounds may also help relax blood vessels, support healthy blood flow, and reduce inflammation. The seed oil contains unique fatty acids, and the peel is especially rich in tannins.

It is important to note that much of this information comes from laboratory and animal studies. How well these effects occur in the human body, and at what doses, is still not fully understood.

Effectiveness

Does Pomegranate work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 27 uses evaluated
1 Possibly effective 2 Leans ineffective 24 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Hypertension
Rating & evidence shown verbatim from Natural Medicines

Oral pomegranate juice seems to modestly reduce blood pressure.

Possibly Ineffective Diabetes
Rating & evidence shown verbatim from Natural Medicines

Most oral pomegranate products do not seem to be beneficial for diabetes. It is unclear if pomegranate seed powder is beneficial.

Possibly Ineffective Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

Oral pomegranate does not seem to be beneficial for hyperlipidemia.

Also studied for 24 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Atherosclerosis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for preventing atherosclerosis.

Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate extract is beneficial for athletic performance.

Insufficient Reliable Evidence To Rate Chronic obstructive pulmonary disease (COPD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for COPD.

Insufficient Reliable Evidence To Rate Coronary heart disease (CHD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for patients with CHD.

Insufficient Reliable Evidence To Rate Dental plaque
Rating & evidence shown verbatim from Natural Medicines

It is unclear if rinsing the mouth with pomegranate extract is beneficial for reducing dental plaque.

Insufficient Reliable Evidence To Rate Erectile dysfunction (ED)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for ED.

Insufficient Reliable Evidence To Rate Exercise-induced muscle soreness
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for reducing exercise-induced muscle soreness.

Insufficient Reliable Evidence To Rate HIV/AIDS
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral pomegranate for HIV/AIDS, there is insufficient reliable information about the clinical effects of pomegranate for this condition.

Insufficient Reliable Evidence To Rate Influenza
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral pomegranate for influenza prevention, there is insufficient reliable information about the clinical effects of pomegranate for this purpose.

Insufficient Reliable Evidence To Rate Intrauterine growth restriction (IUGR)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for preventing brain injury in IUGR neonates.

Insufficient Reliable Evidence To Rate Kidney failure
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for patients on hemodialysis; the available research is conflicting.

Insufficient Reliable Evidence To Rate Menopausal symptoms
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate seed oil or pomegranate extract is beneficial for menopausal symptoms.

Insufficient Reliable Evidence To Rate Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for metabolic syndrome.

Insufficient Reliable Evidence To Rate Muscle strength
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for increasing muscle strength.

Insufficient Reliable Evidence To Rate Nonalcoholic fatty liver disease (NAFLD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate seed oil or pomegranate extract improves anthropometric measures in adults with NAFLD.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate is beneficial for obesity. Most evidence suggests that it is not beneficial, although some studies have yielded conflicting findings.

Insufficient Reliable Evidence To Rate Oropharyngeal candidiasis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical pomegranate peel extract is beneficial for oropharyngeal candidiasis.

Insufficient Reliable Evidence To Rate Polycystic ovary syndrome (PCOS)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate juice is beneficial for PCOS.

Insufficient Reliable Evidence To Rate Prostate cancer
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate extract or juice is beneficial for prostate cancer.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate extract is beneficial for RA.

Insufficient Reliable Evidence To Rate Rhinosinusitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if intranasal pomegranate extract is beneficial for chronic rhinosinusitis.

Insufficient Reliable Evidence To Rate Stroke
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral pomegranate for stroke recovery, there is insufficient reliable information about the clinical effects of pomegranate for this purpose.

Insufficient Reliable Evidence To Rate Sunburn
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate extract is beneficial for sunburn prevention.

Insufficient Reliable Evidence To Rate Trichomoniasis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral pomegranate extract is beneficial for trichomoniasis.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Pomegranate fruit and juice are generally safe for most people when consumed in normal food amounts. Concentrated extracts and supplements have been studied less, so their long-term safety is less certain.

The peel, root, and stem bark contain higher levels of tannins and other compounds and can be harmful in large amounts. These parts should not be used in concentrated forms without professional guidance.

People with allergies to pomegranate should avoid it. If you have a chronic health condition or take prescription medications, talk with your pharmacist or doctor before using pomegranate supplements.

Pregnancy: Eating the fruit or drinking the juice in normal amounts is likely fine, but concentrated extracts and peel or leaf preparations should be avoided because their safety has not been established. Breastfeeding: Food amounts are likely fine, but there is not enough information on supplements, so use caution and check with your healthcare provider first.

Side effects

Pomegranate is usually well tolerated when eaten as food. Some people may experience mild digestive upset, such as stomach discomfort or diarrhea, especially with large amounts of juice or extract.

Allergic reactions are uncommon but can happen and may include itching, swelling, hives, or trouble breathing. Stop using it and seek medical care right away if these occur.

Highly concentrated extracts made from the peel or root may cause more serious effects because of their tannin content, which is another reason to stick to food forms unless directed otherwise by a professional.

Pomegranate: Reported Adverse Effects

Documented safety reports on Pomegranate from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, pomegranate fruit juice is generally well tolerated. Pomegranate fruit extract and seed oil seem to be well tolerated. Pomegranate root, stem, and peel should not be used orally in large amounts. Topically, pomegranate fruit extract seems to be well tolerated.

Most Common Adverse Effects:

Oral: Diarrhea, flatulence.

Reports by condition
Constipation Gastrointestinal

Orally, pomegranate may cause mild gastrointestinal adverse effects. In one clinical study, drinking pomegranate juice 8 ounces daily caused diarrhea and flatulence in 2% of patients. In another clinical study, taking pomegranate extract (POMx, POM Wonderful LLC) 3000 mg daily caused diarrhea in 10% of patients. This dose of pomegranate extract also caused nausea, abdominal pain, constipation, gastrointestinal upset, and vomiting in a small number of patients.

  1. Forest, C. P., Padma-Nathan, H., and Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study
  2. Paller CJ, Ye X, Wozniak PJ, et al. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis 2013;16(1):50-5.
Hypercholesterolemia Cardiovascular

In one clinical trial, 2% of patients experienced hyperlipidemia and hypertension after consumption of pomegranate juice. However, most clinical research shows that pomegranate does not increase cholesterol or blood pressure and may actually improve these parameters in some patients.

  1. Forest, C. P., Padma-Nathan, H., and Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study
  2. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8.
  3. Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8.
  4. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33.
  5. Esmaillzadeh, A., Tahbaz, F., Gaieni, I., Alavi-Majd, H., and Azadbakht, L. Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia. Int J Vitam.Nutr Res 2006;76(3):147-151.
  6. Wright, H. and Pipkin F. B. Pomegranates (Punica granatum), kiwifruit (Actinidia deliciosa) and blood pressure: a pilot study. Proceedings of the Nutrition Society 2008;67(8):1.
  7. Sohrab G, Sotoodeh G, Siasi F, et al. Effect of pomegranate juice consumption on blood pressure in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism 2008;9:399-405, 470.
Hypotension Immunologic

Orally, pomegranate fruit or seeds may cause allergic reactions. These allergic reactions occur more commonly in people who are allergic to other plants. In rare cases, pomegranate fruit can cause angioedema. Angioedema seems to occur without warning and in people who have eaten pomegranate for many years. Patients should be told to stop eating pomegranate if swelling of the tongue or face develops. In one report, a patient experienced pomegranate-dependent, exercise-induced anaphylaxis. The patient developed widespread urticaria (hives) and lip edema after eating pomegranate seeds and then exercising. In another report, an atopic patient experienced an allergic reaction to pomegranate fruit. Symptoms included urticaria (hives), facial angioedema, and hypotension.

Topically, pomegranate may cause contact hypersensitivity characterized by urticaria (hives), angioedema, rhinorrhea, red itchy eyes, and dyspnea arising within a few minutes of exposure.

  1. Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
  2. Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4.
  3. Gangemi S, Mistrello G, Roncarolo D, et al. Pomegranate-dependent exercise-induced anaphylaxis. J Investig Allergol Clin Immunol 2008;18:491-2.
  4. Enrique E, Utz M, De Mateo JA, et al. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol 2006;96(1):122-3.
  5. Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5.
Urticaria Dermatologic

Topically, pomegranate may cause urticaria (hives) in some patients.

  1. Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single established standard dose for pomegranate. In studies, amounts have varied widely depending on whether the fruit, juice, or extract was used.

If you use a pomegranate supplement, follow the directions on the product label and do not exceed the recommended amount. Enjoying the fresh fruit or a serving of juice is a simple, low-risk way to include it in your diet.

Because product strength and quality can vary, it is a good idea to choose reputable brands and to check with your pharmacist or doctor before starting any concentrated supplement.

Pregnancy & Breastfeeding

Pomegranate & Pregnancy

Possibly Safe

When the fruit or fruit juice is consumed orally and appropriately. There is insufficient reliable information available regarding the safety of using other forms of pomegranate or other parts of the plant during pregnancy or lactation; avoid using.

  1. Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64.
  2. Ross MM, Cherkerzian S, Mikulis ND, et al. A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR. Sci Rep. 2021;11(1):3569.

Pomegranate & Breastfeeding

Possibly Safe

When the fruit or fruit juice is consumed orally and appropriately. There is insufficient reliable information available regarding the safety of using other forms of pomegranate or other parts of the plant during pregnancy or lactation; avoid using.

  1. Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64.
  2. Ross MM, Cherkerzian S, Mikulis ND, et al. A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR. Sci Rep. 2021;11(1):3569.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 27 references that drive our Pomegranate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
  2. Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
  3. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
  4. Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
  5. Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
  6. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
  7. Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
  8. Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. PubMed
  9. Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71:203-17. PubMed
  10. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6. PubMed
  11. Farkas D, Oleson LE, Zhao Y, et al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47:286-94. PubMed
  12. Yeo C, Shon J, Liu K, et al. The effects of pomegranate juice on the pharmacokinetics of simvastatin in healthy Korean subjects (PI-63). Clin Pharmacol Ther 2006;79:23.
  13. Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4:381-93.
  14. Nagata M, Hidaka M, Sekiya H, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5. PubMed
  15. Komperda KE. Potential interaction between pomegranate juice and warfarin. Pharmacotherapy 2009;29:1002-6. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Pomegranate

840 brands in our database make a supplement containing Pomegranate.

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Supplement products with Pomegranate

4,756 products in our database contain Pomegranate. Open any to see its full ingredient list and every drug interaction we check.

1,000 mg Vitamin C Cranberry Pomegranate by Emergen-C Powder 0.3 OZ/Packet · 8.3 G/Packet · 30 Packet(s) View ingredients & interactions 1,000 MG Vitamin C Cranberry-Pomegranate by Emergen-C Powder 0.3 oz. · 8.3 g View ingredients & interactions 10-Day Acai Berry Easy-Cleanse by Applied Nutrition Tablet Or Pill 40 Tablet(s) View ingredients & interactions 120/80 by Advanced Nutrition by Zahler Capsule 60 Capsule(s) View ingredients & interactions 14-Day Acai Berry Cleanse by Applied Nutrition Tablet Or Pill 56 Tablet(s) View ingredients & interactions 14-Day Acai Berry Cleanse by Applied Nutrition Tablet Or Pill 56 Tablet(s) View ingredients & interactions 37 Strawberries by Purity Products Capsule 30 Capsule(s) View ingredients & interactions 4Life Transfer Factor RioVida by 4Life Liquid 2 Bottle(s) View ingredients & interactions 4Life Transfer Factor Riovida by 4Life Liquid 16.9 fl. Oz. · 500 mL View ingredients & interactions 5-Day Acai Berry Cleanse by Applied Nutrition Tablet Or Pill 20 Tablet(s) View ingredients & interactions 5-Day Liquid Cleanse & Flush by Applied Nutrition Liquid 10 Liquid Tube · 100 mL · 3.35 fl. Oz. View ingredients & interactions 6 Pack Keto ACV Gummies by Justified Laboratories Gummy Or Jelly 60 Gummy(ies) View ingredients & interactions 7 Hour Slim by Totally Products Capsule 60 Capsule(s) View ingredients & interactions 9-in-1 Saw Palmetto Prostate Support Gummies Natural Raspberry & Pomegranate Flavor by Bucklebury Gummy Or Jelly 60 Gummy(ies) View ingredients & interactions A.M. by Jigsaw Health Other (e.g. Tea Bag) 30 Nutritional Supplement Packets View ingredients & interactions A.M. by Jigsaw Health Other (e.g. Tea Bag) 60 Nutritional Supplement Packets View ingredients & interactions a2z Chewable Natural Watermelon Flavor by doTERRA Tablet Or Pill 60 Tablet(s) View ingredients & interactions a2z Chewable Strawberry Flavored by doTERRA Tablet Or Pill 60 Tablet(s) View ingredients & interactions Absolute Pomegranate by California Academy of Health Liquid 16 Ounce(s) · 474 mL View ingredients & interactions Absolute Pomegranate Powder by California Academy of Health Powder 8 oz. · 227 Gram(s) View ingredients & interactions Acai by The Vitamin Shoppe Liquid 32 fl. Oz. · 946 mL View ingredients & interactions Acai 600 by Pure Encapsulations Capsule 180 Capsule(s) View ingredients & interactions AcaI Advanced Energy by Isotonix Powder 10.6 Ounce(s) · 300 Gram(s) View ingredients & interactions Acai Advantage by Healthy Choice Naturals Capsule 60 Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Pomegranate: Common Questions

What is Pomegranate used for, and does it work?
People use Pomegranate for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Pomegranate for Hypertension. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Pomegranate interact with prescription medications?
Yes. We list 922 medications with a known interaction with Pomegranate. Use the checker above to see how Pomegranate interacts with a specific drug.
How are Pomegranate interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Pomegranate with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Pomegranate interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Pomegranate used for?
People commonly use Pomegranate for general antioxidant support, heart and blood vessel health, blood pressure, inflammation, and digestive complaints. Most of these uses are based on traditional practice and early research rather than strong proof.
Is Pomegranate juice good for you?
Pomegranate juice is rich in antioxidants and can be part of a healthy diet. Keep in mind it also contains natural sugars and calories, so unsweetened versions in moderate amounts are best, especially if you watch your blood sugar.
Is it safe to take Pomegranate supplements during pregnancy?
Eating the fruit or drinking the juice in normal amounts is likely fine, but concentrated extracts and peel or leaf products should be avoided during pregnancy because their safety is not well studied. Check with your doctor first.
Can Pomegranate cause side effects?
As a food it rarely causes problems, but large amounts of juice or extract can lead to stomach upset or diarrhea. Allergic reactions are uncommon but possible, so stop use and get medical help if you notice swelling, hives, or trouble breathing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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