Pyruvate Interactions Overview

Check For Interactions With Pyruvate

Pyruvate

Also known as
  • 2-Oxopropanoate
Pyruvate, also known as alpha-ketocarboxylic acid, is an organic acid containing three carbon atoms. Within the body, it is produced through glycolysis, a metabolic pathway that converts glucose into pyruvate. Pyruvate plays a crucial role in the cellular energy production process. It can either be further broken down in the presence of oxygen to produce more energy through aerobic respiration or be converted into lactate in the absence of oxygen during anaerobic respiration, making it an essential molecule for sustaining cellular metabolism.
There are 0 drugs known to interact with Pyruvate

Additional Details

Is Pyruvate Safe? Are There Any Warnings?

Pyruvate is generally considered safe when used orally, topically, or inhaled in appropriate doses for short-term use. Some common side effects include bloating, diarrhea, flatulence, and a burning sensation at high concentrations. However, there is insufficient information available on the safety of pyruvate during pregnancy and lactation, so it is recommended to avoid using it during these times.

How Is Pyruvate Thought To Work? What is the Mechanism of Action?

Pyruvate is a three-carbon organic acid that is formed in the body during glycolysis, a metabolic process that converts glucose to pyruvate.

It plays a crucial role in energy production by producing adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NADH) through anaerobic metabolism.

Pyruvate can further undergo aerobic or anaerobic metabolism, resulting in the production of lactate through anaerobic metabolism and fatty acids and carbohydrates through aerobic metabolism. These metabolic processes contribute to various effects of pyruvate, including anti-inflammatory, anti-tumor, cardioprotective, dermatologic, glucose metabolism, ocular, and weight loss effects.

Pharmacokinetics

Pyruvate is well absorbed by the body, especially when topically applied. It can be metabolized through aerobic or anaerobic pathways, where anaerobic metabolism produces lactate and aerobic metabolism produces fatty acids and carbohydrates. The precise pharmacokinetics of pyruvate are not well-studied in humans.

Interaction Overview

There are no known interactions between pyruvate and drugs or supplements. However, it is always advisable to consult with a healthcare professional before starting any new supplement to mitigate potential risks.

Common Side Effects to Watch For

Common side effects of oral pyruvate include bloating, diarrhea, and flatulence. When applied topically, it may cause a burning sensation at higher concentrations. A healthcare professional should be consulted if any severe or persistent side effects occur.

Are Supplements Standardized?

Most clinical studies that have evaluated pyruvate have primarily used sodium pyruvate or calcium pyruvate as standardized forms. These forms ensure consistent dosing and reliable results in research.

What Is Pyruvate Typically Used For?

Pyruvate has shown evidence of effectiveness in improving acne severity when applied topically and in aiding weight loss when taken orally along with a proper diet and exercise regime.

It may also have potential benefits in alcohol-related liver disease, COPD, congestive heart failure, glaucoma, hyperlipidemia, and certain dermatologic conditions. However, more research is needed to establish its effectiveness for these uses.

Drugs that interact with Pyruvate

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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