White Mulberry Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how White Mulberry interacts with medications. The heart of this page is the interaction list — every drug White Mulberry is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what White Mulberry is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check White Mulberry against your medication
Add one medicationWhite Mulberry Drug Interactions: The Bottom Line
From the HelloPharmacist Editorial Team · Updated July 2026Based on the available evidence, the overall risk of a clinically significant White Mulberry drug interaction appears low for most people, though it deserves real attention if you take medicines for blood sugar. None of the listed interactions are rated major, and the concerns behind them rest mostly on theoretical or animal research rather than well-documented human studies.
The interaction that stands out most involves diabetes medications. Clinical research shows white mulberry leaf can lower blood glucose on its own, so combining it with drugs that do the same thing could push blood sugar lower than intended, which matters for anyone whose glucose is closely managed. The other concern involves medicines the kidneys clear through a transporter, such as metformin; animal research suggests white mulberry may slow how quickly the body removes these drugs, which could raise their levels.
The long list of interacting medications largely traces back to those two effects, especially the kidney transporter one, which is predicted rather than proven in people. In other words, most listed combinations reflect what could theoretically happen, not what has been shown to cause meaningful problems in humans.
Based on HelloPharmacist’s White Mulberry interaction data and reviewed under our editorial standards.
Drugs that interact with White Mulberry
87 medications have a known interaction with White Mulberry, graded by severity. Select any drug for the full evidence-based detail.
Don’t want to scroll the list? Just ask.
Tell us the medications you take and we’ll check each one against White Mulberry using our pharmacist-reviewed interaction data.
AI summaries are generated from our White Mulberry interaction data for education only — always confirm with your pharmacist. How we use AI
No drugs match “”.
AcarboseGlucobay, Prandase, Precose
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Acarbose interaction Acarbose drug page: uses, dosage & side effectsAcetohexamideDymelor
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Acetohexamide interactionAlbiglutideTanzeum
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Albiglutide interactionAlogliptinNesina
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Alogliptin interaction Alogliptin drug page: uses, dosage & side effectsAlogliptin, MetforminKazano
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Alogliptin, Pioglitazone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Canagliflozin interaction Canagliflozin drug page: uses, dosage & side effectsCanagliflozin, MetforminInvokamet
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Chlorpropamide interactionDapagliflozinFarxiga
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Dapagliflozin interaction Dapagliflozin drug page: uses, dosage & side effectsDapagliflozin Propanediol, MetforminXigduo XR
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Dasiglucagon Hydrochloride interaction Dasiglucagon Hydrochloride drug page: uses, dosage & side effectsDulaglutideTrulicity
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Dulaglutide interaction Dulaglutide drug page: uses, dosage & side effectsEmpagliflozinJardiance
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Empagliflozin interaction Empagliflozin drug page: uses, dosage & side effectsEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Ertugliflozin interaction Ertugliflozin drug page: uses, dosage & side effectsErtugliflozin, Metformin HydrochlorideSegluromet
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Exenatide interaction Exenatide drug page: uses, dosage & side effectsExenatide SyntheticBydureon BCISE
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Exenatide Synthetic interaction Exenatide Synthetic drug page: uses, dosage & side effectsGliclazideDiamicron
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Gliclazide interactionGlimepirideAmaryl
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Glimepiride interaction Glimepiride drug page: uses, dosage & side effectsGlipizideGlucotrol, Glucotrol XL
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Glipizide interaction Glipizide drug page: uses, dosage & side effectsGlipizide, MetforminMetaglip
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Glucagon interaction Glucagon drug page: uses, dosage & side effectsGlucoseIV Glucose
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Glucose interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Glyburide interaction Glyburide drug page: uses, dosage & side effectsGlyburide, MetforminGlucovance
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Glyburide, Metformin interactionInhaled InsulinExubera
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Inhaled Insulin interactionInsulinNovoRapid Insulin
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin interactionInsulin (bovine)Hypurin Bovine Neutral
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin (bovine) interactionInsulin (human)Afrezza, Novolin 70/30, Novolin L, Novolin N, Novolin R
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin (human) interaction Insulin (human) drug page: uses, dosage & side effectsInsulin (pork)Hypurin Porcine Neutral, Lente Iletin II, NPH Iletin, NPH Iletin II, Pork Actrapid, Regular Iletin +1 more
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin (pork) interactionInsulin (rdna)Actrapid, Humalog, Humalog Mix 75/25, Humulin 50/50, Humulin 70/30, Humulin L +8 more
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin (rdna) interaction Insulin (rdna) drug page: uses, dosage & side effectsInsulin AspartFiasp
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Aspart interaction Insulin Aspart drug page: uses, dosage & side effectsInsulin Aspart, Insulin DegludecRyzodeg 70/30
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Aspart, Insulin Degludec interactionInsulin DegludecTresiba
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Degludec interaction Insulin Degludec drug page: uses, dosage & side effectsInsulin Degludec, LiraglutideXultophy 100/3.6
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Degludec, Liraglutide interactionInsulin GlargineBasaglar, Lusduna, Semglee
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Glargine interaction Insulin Glargine drug page: uses, dosage & side effectsInsulin Glargine (rdna)Lantus
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Glargine (rdna) interaction Insulin Glargine (rdna) drug page: uses, dosage & side effectsInsulin Glargine RecombinantToujeo Solostar
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Glargine Recombinant interactionInsulin Glargine, LixisenatideSoliqua 100/33
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Glargine, Lixisenatide interactionInsulin Glulisine (rdna)Apidra
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Glulisine (rdna) interaction Insulin Glulisine (rdna) drug page: uses, dosage & side effectsInsulin Human, Sodium ChlorideMyxredlin
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Human, Sodium Chloride interaction Insulin Human, Sodium Chloride drug page: uses, dosage & side effectsInsulin LisproAdmelog, Admelog Solostar
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Lispro interaction Insulin Lispro drug page: uses, dosage & side effectsInsulin Lispro RecombinantHumalog Kwikpen
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Lispro Recombinant interactionInsulin Lispro-aabcLyumjev
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Lispro-aabc interactionInsulin DetermirLevemir
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Insulin Determir interaction Insulin Determir drug page: uses, dosage & side effectsLinagliptinTradjenta
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Linagliptin interaction Linagliptin drug page: uses, dosage & side effectsLinagliptin, Metformin HydrochlorideJentadueto XR
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Linagliptin, Metformin Hydrochloride interactionLiraglutideVictoza
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Liraglutide interaction Liraglutide drug page: uses, dosage & side effectsLiraglutide RecombinantSaxenda
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Liraglutide Recombinant interaction Liraglutide Recombinant drug page: uses, dosage & side effectsLixisenatideAdlyxin
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Lixisenatide interaction Lixisenatide drug page: uses, dosage & side effectsMetforminGlucophage, Metformin
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Metformin interaction Metformin drug page: uses, dosage & side effectsMetformin HydrochlorideRiomet ER
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Metformin Hydrochloride interactionMetformin XrGlucophage XR
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Metformin Xr interactionMetformin, LinagliptinJentadueto
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Metformin, Sitagliptin interactionMiglitolGlyset
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Miglitol interaction Miglitol drug page: uses, dosage & side effectsMuraglitazarPargluva
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Muraglitazar interactionNateglinideStarlix
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Nateglinide interaction Nateglinide drug page: uses, dosage & side effectsPioglitazoneActos
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Pioglitazone interaction Pioglitazone drug page: uses, dosage & side effectsPramlintideSymlin
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Pramlintide interaction Pramlintide drug page: uses, dosage & side effectsRepaglinideGlucoNorm, Prandin
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Repaglinide interaction Repaglinide drug page: uses, dosage & side effectsRosiglitazone MaleateAvandia
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Rosiglitazone Maleate interaction Rosiglitazone Maleate drug page: uses, dosage & side effectsSaxagliptinOnglyza
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Saxagliptin interaction Saxagliptin drug page: uses, dosage & side effectsSaxagliptin, Metformin XrKombiglyze
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Saxagliptin, Metformin Xr interactionSemaglutideOzempic, Rybelsus, Wegovy
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Semaglutide interaction Semaglutide drug page: uses, dosage & side effectsSimvastatin, SitagliptinJuvisync
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Simvastatin, Sitagliptin interactionSitagliptinJanuvia, Zituvio
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Sitagliptin interaction Sitagliptin drug page: uses, dosage & side effectsSitagliptin, MetforminZituvimet
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Sitagliptin, Metformin interactionSotagliflozinInpefa
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Sotagliflozin interactionTirzepatideMounjaro, Zepbound
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Tirzepatide interaction Tirzepatide drug page: uses, dosage & side effectsTobutamideMobenol
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Tobutamide interactionTolazamideTolinase
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Tolazamide interaction Tolazamide drug page: uses, dosage & side effectsTolbutamideOrinase
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Tolbutamide interaction Tolbutamide drug page: uses, dosage & side effectsTroglitazoneRezulin
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Troglitazone interactionVareniclineChampix, Chantix, Tyrvaya
Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Read the full White Mulberry + Varenicline interaction Varenicline drug page: uses, dosage & side effectsVildagliptinGalvus
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Vildagliptin interactionPioglitazone, MetforminActoPlus Met
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Pioglitazone, Metformin interactionRosiglitazone, GlimepirideAvandaryl
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full White Mulberry + Rosiglitazone, Glimepiride interactionWhat Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact White Mulberry combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The kinds of drugs White Mulberry affects
Every type of medication (drug category) White Mulberry is known to interact with. Open any category for the detail — or search your exact drug in the checker above.
Antidiabetes Drugs
Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.
Organic Cation Transporter 2 (Oct2) Substrates
Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.
White Mulberry: Uses, Safety & Side Effects
White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea, but talk to your pharmacist or doctor before using concentrated supplements, especially if you take diabetes medicine.

- Scientific name
- Morus alba
- Family
- Moraceae
- Part used
- Leaves, fruit (berries), root bark, and twigs
- Common forms
- Capsules, tablets, leaf tea, powdered leaf extract, dried fruit, liquid extracts
- Blood sugar support
- High cholesterol
- Weight management
- Antioxidant support
- High blood pressure (traditional use)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Likely safe as a food, but concentrated supplements are less studied and may lower blood sugar.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
White mulberry (Morus alba) is a deciduous tree that is native to China but now grows in many parts of the world, including Europe, the United States, and the Middle East. It has long been important in silk farming because silkworms feed on its leaves.
People eat the sweet white-to-pinkish berries fresh or dried, and the leaves, root bark, and twigs have a long history in traditional Chinese and other folk medicine systems. Today, white mulberry leaf is commonly sold as a capsule, tablet, powder, or tea, often marketed for blood sugar and weight support.
It is worth noting that white mulberry (Morus alba) is a different species from black mulberry (Morus nigra), even though both belong to the same plant genus.
How it works
White mulberry leaf contains a compound called 1-deoxynojirimycin (DNJ), which can block enzymes in the gut that break down complex sugars. By slowing this process, less sugar is absorbed quickly, which may lessen the rise in blood sugar after eating.
The plant also contains flavonoids, polyphenols, and anthocyanins (especially in the fruit) that act as antioxidants in laboratory tests. Researchers have studied these compounds for possible effects on cholesterol and inflammation.
Most of these mechanisms come from test-tube and animal studies, so it is not certain how strongly they apply to people taking supplements.
Does White Mulberry work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For White Mulberry, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 9 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Androgenic alopecia
Although there has been interest in using oral white mulberry for androgenic alopecia, there is insufficient reliable evidence about the clinical effects of white mulberry for this purpose.
Insufficient Reliable Evidence To Rate Common cold
Although there has been interest in using oral white mulberry for symptoms of the common cold, including cough and sore throat, there is insufficient reliable evidence about the clinical effects of white mulberry for this purpose.
Insufficient Reliable Evidence To Rate Diabetes
While research is mixed, most small clinical studies suggest that oral white mulberry does not reduce fasting blood glucose or glycated hemoglobin (HbA1c) in patients with type 2 diabetes; however, it does seem to improve insulin resistance and postprandial blood glucose in these patients.
Insufficient Reliable Evidence To Rate Hyperlipidemia
It is unclear if oral white mulberry is beneficial in patients with hyperlipidemia; the available research has mixed results.
Insufficient Reliable Evidence To Rate Hypertension
Although there has been interest in using oral white mulberry for hypertension, there is insufficient reliable evidence about the clinical effects of white mulberry for this purpose.
Insufficient Reliable Evidence To Rate Impaired glucose tolerance (prediabetes)
It is unclear if oral white mulberry is beneficial in patients with impaired glucose tolerance.
Insufficient Reliable Evidence To Rate Joint pain
Although there has been interest in using oral white mulberry for joint pain, including joint pain associated with osteoarthritis and rheumatoid arthritis (RA), there is insufficient reliable information about the clinical effects of white mulberry for these conditions.
Insufficient Reliable Evidence To Rate Obesity
It is unclear if oral white mulberry can reduce body weight in patients who are obese or overweight.
Insufficient Reliable Evidence To Rate Osteoporosis
Although there has been interest in using oral white mulberry for osteoporosis, there is insufficient reliable evidence about the clinical effects of white mulberry for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
White mulberry fruit is widely eaten as a food and is generally considered safe in normal food amounts. Leaf supplements and teas appear to be well tolerated by most healthy adults in the short term, but long-term safety has not been well studied.
Because white mulberry may lower blood sugar, people with diabetes or those taking blood-sugar-lowering medicines should use caution and monitor their blood sugar, since levels could drop too low. If you are scheduled for surgery, it may be wise to stop using it beforehand because of possible blood sugar effects.
For pregnancy and breastfeeding, there is not enough reliable safety information. To be safe, avoid medicinal or supplement amounts during these times and stick to ordinary food amounts of the berries only if your doctor agrees.
Always talk with your pharmacist or doctor before starting white mulberry, especially if you have a medical condition or take prescription medicine.
Side effects
White mulberry is usually well tolerated. The most common side effects are mild and digestive, such as bloating, gas, loose stools, nausea, or stomach upset, especially with the leaf or concentrated extracts.
Because it may lower blood sugar, watch for symptoms of low blood sugar such as dizziness, shakiness, sweating, or confusion, particularly if you also take diabetes medicine.
Allergic reactions are possible but uncommon. Stop use and seek medical care if you notice rash, itching, swelling, or trouble breathing.
White Mulberry: Reported Adverse Effects
Documented safety reports on White Mulberry from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, white mulberry leaf seems to be well tolerated.
Most Common Adverse Effects:
Orally: Transient bloating, constipation, flatulence, and loose stools.
Constipation Gastrointestinal
Orally, white mulberry leaf powder 4.6 grams three times daily for 4 weeks was associated with bloating and flatulence in 50% of patients, loose stools in 25% of patients, and constipation in 21% of patients in one clinical study. However, reports of these adverse effects decreased over the course of the 12-week study, suggesting that for some patients the adverse effects may be transient in nature.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no officially established standard dose for white mulberry supplements. Doses used in studies have varied widely depending on the plant part and extract, and there is not enough consistent research to recommend a specific milligram amount.
If you choose to use it, follow the directions on the product label and do not exceed the suggested amount. White mulberry leaf is often taken with or just before a meal when used for blood sugar support.
Because product strength and quality can vary a lot, choose a reputable brand and check with your pharmacist or doctor about whether it is appropriate for you and what dose makes sense.
White Mulberry & Pregnancy
White Mulberry & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 6 references that drive our White Mulberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
- Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
- Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
- Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
- Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
- Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with White Mulberry
104 brands in our database make a supplement containing White Mulberry.
Supplement products with White Mulberry
282 products in our database contain White Mulberry. Open any to see its full ingredient list and every drug interaction we check.
White Mulberry: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain White Mulberry
A rotating sample of real supplements in our database that list White Mulberry — open any to see its full ingredients and every drug interaction we check.
- White Mulberry Extract by BulkSupplements.com
- Sang Bai Pi by Hawaii Pharm
- Sinetrim With Sinetrol by BioGenetic Laboratories
- Lungs Mucus by Professional Botanicals
- Quiet Cough Teapills by Plum Flower
- Greens Berry by Bowmar Nutrition
- Young Lungs by Ron Teeguarden's Dragon Herbs
- Weight Loss4 Gummies Raspberry Flavor by Doctor's Select Nutraceuticals
- Sang Bai Pi by Herbal Terra
- Biotae by Merry Clinic
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