Hydrazine Sulfate - Rifamate (Isoniazid, Rifampin) Interaction
Herbal: Hydrazine Sulfate
Drug: Isoniazid, Rifampin
Brand names:
Rifamate
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Isoniazid, Rifampin is classified as belonging to the following category: Isoniazid
Theoretically, concurrent use of isoniazid and hydrazine sulfate might increase the risk for liver damage.
Hydrazine sulfate is a metabolite of isoniazid. Animal research shows that hydrazine sulfate might be responsible for isoniazid-induced hepatotoxicity.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Sarich TC, Adams SP, Petricca G, Wright JM. Inhibition of isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidase inhibitor. J Pharmacol Exp Ther 1999;289:695-702.
Hydrazine Sulfate - More Interactions
Hydrazine Sulfate interacts with 96 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.