Interaction Details

There were no interactions found between Niacin (prescription drug) and Hyland's Restless Legs. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.


Still looking for more information about combining Niacin (prescription drug) and Hyland's Restless Legs? Ask Dr. Brian Staiger about it by contacting him directly.

Pharmacist Analysis

In most situations, clinically significant interactions between homeopathic products and prescription or over-the-counter medications are extremely unlikely.

Homeopathic medications, which utilize the principle of 'like cures like', are often highly diluted substances. These dilutions are typically so high that the final remedy contains only a tiny amount of the original active ingredient, if any at all.

In theory, because the concentration of the active ingredient is so low, homeopathic preparations are unlikely to interact with other medications in the body.

This is certainly the case with Hyland's Restful Legs, with all the ingredients diluted at potencies of 6X or 12X. A potency of 6X means that the original substance has been diluted by a factor of 10^6, or one part in a million (i.e.,  for every million parts of the solution, there is one part of the original substance).

It is important to note that not all homeopathic remedies are free of potential drug interactions as some use very low dilutions (which is often the case with zinc-containing products).

Nevertheless, there are no known drug interactions between Hyland's Restful Legs and other medications. It is also thought to be safe to take along with medications to help sleep, like Benadryl, melatonin, and NyQuil, which are commonly used with the product to help sleep.

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Hyland's Restless Legs Overview

Hyland's Restless Legs Hyland's Restless Legs (the actual product name is Hyland's Restful Legs but it is more commonly known as 'restless legs') is a homeopathic product that is marketed to 'calm agitated legs so you can rest.' As a homeopathic product, Restul Legs is based on the principle of "like cures like" or 'law of similars', meaning that a substance that causes symptoms in a healthy person can be used in a diluted form to treat similar symptoms (such as an onion preparation being used to treat watery eyes and a runny nose). A good example of this is that Restful Legs contain Arsenicum Album 12X, a highly diluted form of arsenic. There is both a daytime version of Hyland's Restless Legs and a nighttime version (PM).
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Niacin (prescription drug) Overview

  • Niacin is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol (a fat-like substance) and other fatty substances in your blood and to increase the amount of high density lipoprotein (HDL; ''good cholesterol''). Niacin can be used in a number of situations including the following:

    • alone or in combination with other medications, such as HMG-CoA inhibitors (statins) or bile acid-binding resins;

    • to decrease the risk of another heart attack in patients with high cholesterol who have had a heart attack;

    • to prevent worsening of atherosclerosis (buildup of cholesterol and fats along the walls of the blood vessels) in patients with high cholesterol and coronary artery disease;

    • to reduce the amount of triglycerides (other fatty substances) in the blood in patients with very high triglycerides who are at risk of pancreatic disease (conditions affecting the pancreas, a gland that produces fluid to break down food and hormones to control blood sugar).

  • Niacin is also used to prevent and treat pellagra (niacin deficiency), a disease caused by inadequate diet and other medical problems. Niacin is a B-complex vitamin. At therapeutic doses, niacin is a cholesterol-lowering medication.

  • Results of a clinical study in people with heart disease and well-controlled cholesterol levels that compared people who took niacin and simvastatin with people who took simvastatin alone and found similar results for the two groups in the rate of heart attacks or strokes. Taking niacin along with simvastatin or lovastatin also has not been shown to reduce the risk of heart disease or death compared with the use of niacin, simvastatin, or lovastatin alone. Talk to your doctor if you have questions about the risks and benefits of treating increased amounts of cholesterol in your blood with niacin and other medications.

See More Information Regarding Niacin

Hyland's Restless Legs - More Interactions

Hyland's Restless Legs interacts with 0 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Ask A Pharmacist About Your Herbal Questions!

Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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