Indian Long Pepper - Declomycin (Demeclocycline) Interaction
Herbal: Indian Long Pepper
Also Known As: Piper longum, Bi Ba, Bi Bo, Jaborandi Pepper, Kana, Langer Pfeffer, Lindipipper, Long Pepper, Magadhi, Magdhi, Pibo, Pimienta Larga, Pimenta-Longa, Pippali, Pippli, Poivre Long, Poivrier Long, Poivrier Long d'Inde, Poivre Long Indien, Ushana
Drug: Demeclocycline
Brand names:
Declomycin
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Demeclocycline is classified as belonging to the following category: P-Glycoprotein Substrates
Theoretically, Indian long pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of Indian long pepper, can inhibit P-glycoprotein.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50.
- Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289.
Indian Long Pepper Overview
Demeclocycline Overview
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Demeclocycline is used to treat infections caused by bacteria includingpneumonia and other respiratory tract infections;; certain infections of the skin, eye, lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used along with other medications to treat acne. Demeclocycline is also used to treat plague and tularemia (serious infections that may be spread on purpose as part of a bioterror attack). Demeclocycline can also be used in patients who cannot be treated with penicillin to treat certain types of food poisoning and anthrax (a very serious infection that may be spread on purpose as part of a bioterror attack), Demeclocycline is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria.
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Antibiotics such as demeclocycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Indian Long Pepper - More Interactions
Indian Long Pepper interacts with 849 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.