Indian Long Pepper - Tivicay (Dolutegravir) Interaction
Herbal: Indian Long Pepper
Also Known As: Piper longum, Bi Ba, Bi Bo, Jaborandi Pepper, Kana, Langer Pfeffer, Lindipipper, Long Pepper, Magadhi, Magdhi, Pibo, Pimienta Larga, Pimenta-Longa, Pippali, Pippli, Poivre Long, Poivrier Long, Poivrier Long d'Inde, Poivre Long Indien, Ushana
Drug: Dolutegravir
Brand names:
Tivicay
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Dolutegravir is classified as belonging to the following category: P-Glycoprotein Substrates
Theoretically, Indian long pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of Indian long pepper, can inhibit P-glycoprotein.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50.
- Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289.
Indian Long Pepper Overview
Indian long pepper, also known as pippali or pipali, is a plant species native to India and other parts of South and Southeast Asia. It is a member of the Piperaceae family. The fruit of the plant, which has a pungent, slightly sweet flavor, is harvested and dried for use as a spice.
Indian long pepper has also been used in Ayurvedic medicine to treat a variety of ailments, including digestive problems, pain, poor blood circulation, respiratory disorders, and fever. One of the constituents of Indian long pepper is piperine, which can have wide ranging effects, including increasing the bioavailability (i.e., rate and extent of absorption) of several different drugs. It is often combined with over-the-counter supplements, like turmeric, to increase their absorption.
Dolutegravir Overview
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Dolutegravir is used with other medications to treat human immunodeficiency virus (HIV) infection in adults and children 4 weeks of age and older who weigh at least 6.6 lbs (3 kg). It is also used in combination with rilpivirine (Edurant) to treat HIV in certain adults to replace their current HIV medication(s) that has been taken for at least 6 months. Dolutegravir is in a class of medications called HIV integrase inhibitors. It works by decreasing the amount of HIV in your blood and increasing the number of immune cells that help fight infections in your body. Although dolutegravir does not cure HIV, using it along with other medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting (spreading) the HIV virus to other people.
Indian Long Pepper - More Interactions
Indian Long Pepper interacts with 849 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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