Inositol Nicotinate - Qternmet XR (Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride) Interaction
Herbal: Inositol Nicotinate
Also Known As: Hexaniacinate d'Inositol, Hexanicotinoyl Inositol, Inositol Hexaniacinate, Inositol Hexanicotinate, Inositol Niacinate, Meso-Inositol Hexanicotinate, Nicotinato de Inositol, No-Flush Niacin
Drug: Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride
Brand names:
Qternmet XR
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Inositol nicotinate is metabolized to niacin in the body. Niacin can cause hyperglycemia, abnormal glucose tolerance, and glycosuria. Increased blood glucose monitoring may be necessary, particularly early in the course of treatment.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
- Crouse JR III. New developments in the use of niacin for treatment of hyperlipidemia: new considerations in the use of an old drug. Coron Artery Dis 1996;7:321-6.
- Garg A, Grundy SM. Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. JAMA 1990;264:723-6.
- McKenney J. New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med 2004;164:697-705.
Inositol Nicotinate Overview
Inositol nicotinate is a compound formed from the combination of inositol and nicotinic acid (also known as niacin). It is sometimes used as a dietary supplement, with claims that it has various health benefits such as increasing blood flow and improving circulation, as well as lowering cholesterol levels and treating other conditions such as anxiety and depression.
Inositol Nicotinate - More Interactions
Inositol Nicotinate interacts with 217 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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