Inositol Nicotinate - Roszet (Rosuvastatin Calcium, Ezetimibe) Interaction
Herbal: Inositol Nicotinate
Also Known As: Hexaniacinate d'Inositol, Hexanicotinoyl Inositol, Inositol Hexaniacinate, Inositol Hexanicotinate, Inositol Niacinate, Meso-Inositol Hexanicotinate, Nicotinato de Inositol, No-Flush Niacin
Drug: Rosuvastatin Calcium, Ezetimibe
Brand names:
Roszet
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Rosuvastatin Calcium, Ezetimibe is classified as belonging to the following category: Hmg-Coa Reductase Inhibitors ("Statins")
Theoretically, concomitant use of inositol nicotinate and statins might increase the risk of myopathy and rhabdomyolysis.
Inositol nicotinate is metabolized to niacin in the body. Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins However, a significantly increased risk of myopathy has not been demonstrated in clinical trials.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93.
- Bays HE, Dujovne CA. Drug interactions of lipid-altering drugs. Drug Saf 1998;19:355-71.
- McKenney J. New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med 2004;164:697-705.
- Reaven P, Witztum JL. Lovastatin, nicotinic acid and rhabdomyolysis (letter). Ann Int Med 1988;109:597-8.
- Ito MK. Advances in the understanding and management of dyslipidemia: using niacin-based therapies. Am J Health-Syst Pharm 2003;60(suppl 2):s15-21.
- Garnett WR. Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors. Am J Health Syst Pharm. 1995;52(15):1639-45.
Inositol Nicotinate Overview
Inositol nicotinate is a compound formed from the combination of inositol and nicotinic acid (also known as niacin). It is sometimes used as a dietary supplement, with claims that it has various health benefits such as increasing blood flow and improving circulation, as well as lowering cholesterol levels and treating other conditions such as anxiety and depression.
Inositol Nicotinate - More Interactions
Inositol Nicotinate interacts with 217 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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