Jiaogulan - Glucophage XR (Metformin XR) Interaction
Herbal: Jiaogulan
Also Known As: Gynostemma pentaphyllum, Adaptogen, Adaptogène, Amachazuru, Dungkulcha, Fairy Herb, Ginseng du Sud, Gynostemma, Herbe de l'Immortalité, Immortality Herb, Jiao Chu Lan, Jiao Gu Lan, Miracle Grass, Penta Tea, Plante de l'Immortalité, Southern Ginseng
Drug: Metformin XR
Brand names:
Glucophage XR
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Metformin XR is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that jiaogulan can lower blood glucose levels.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383.
- Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313.
- Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7.
Jiaogulan Overview
Jiaogulan (Gynostemma pentaphyllum) is a plant native to China and is known as "Southern Ginseng" or "Five-Leaf Gynostemma," due to its close resemblance to ginseng and the five leaflets on its leaves. It has also been called 'Miracle Plant'.
It is a climbing vine that grows in warm, humid regions and has been used in traditional Chinese medicine to treat a wide range of ailments, including fatigue, stress, high blood sugar and high blood pressure. It is also believed to have anti-aging and immune-boosting properties. Hundreds of different compounds have been found in Jiaogulan, some of which have found to be somewhat similar, or even identical, to those found in other plants, such as Panax ginseng.
Jiaogulan - More Interactions
Jiaogulan interacts with 311 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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