Kaolin - Coptin (Sulfadiazine, Trimethoprim) Interaction
Herbal: Kaolin
Also Known As: Hydrated aluminum silicate, White Bole
Drug: Sulfadiazine, Trimethoprim
Brand names:
Coptin
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Sulfadiazine, Trimethoprim is classified as belonging to the following category: Trimethoprim (Proloprim)
Kaolin may reduce the absorption of trimethoprim. To avoid a potential interaction, separate trimethoprim and kaolin doses by at least 3 hours.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Babhair SA, Tariq M. Effect of magnesium trisilicate and kaolin-pectin on the bioavailability of trimethoprim. Res Commun Chem Pathol Pharmacol 1983;40:165-8.
- Electronic Code of Federal Regulations. Title 21. Part 335 - Antidiarrheal drug products for over-the-counter human use. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=335.50
Kaolin Overview
Kaolin - More Interactions
Kaolin interacts with 6 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.