Miracle Fruit - Tolvaptan Interaction
Herbal: Miracle Fruit
Also Known As: Synsepalum dulcificum, Bumelia dulcifica, Richadellla dulcifica, Sideroxylon dulcificum, Agbayun, Fruit Miracle, Magic Berry, Miracle Berry, Miraculin, Miraculous Berry, Sweet Berry
Drug: Tolvaptan
Brand names:
Samsca, Jynarque
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 23, 2024
Interaction Details
There were no interactions found between Tolvaptan and Miracle Fruit. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Miracle Fruit Overview
Miracle fruit, also known as synsepalum dulcificum, is a small red berry native to West Africa. The active ingredient in the berry, called miraculin, temporarily alters the taste buds on the tongue, making sour and acidic foods taste sweet. Due to the effects of miraculin, it is sometimes used as a sugar substitute for people with diabetes or for those looking to reduce their sugar intake. The effects of miraculin can last for up to an hour after consumption. In addition to its use as a natural medicine, miracle berry is also commonly used as a novelty product (e.g., 'mberry miracle berry tablets'), promoted as a fun addition to parties and gatherings, where it is often used as part of a “flavor tripping” experience, where people consume sour and acidic foods, such as lemons or vinegar, and experience the change in taste sensation.
Tolvaptan Overview
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Tolvaptan (Jynarque) is used to slow the worsening of kidney function in certain patients with autosomal dominant polycystic kidney disease (ADPKD; a certain type of inherited kidney disease). Tolvaptan (Jynarque) is in a class of medications called vasopressin V2 receptor antagonists. It works by increasing the amount of water released from the body as urine and decreases the growth of cysts in the kidneys. Removing fluid from the body and slowing the growth of cysts helps to slow the worsening of kidney function.
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Tolvaptan is also available as a tablet (Samsca) to treat low blood levels of sodium in people who have heart failure or certain other conditions. This monograph only gives information about tolvaptan tablets (Jynarque) to slow the worsening of kidney function in patients with ADPKD. If you are using this medication to treat low levels of sodium in the blood, read the monograph entitled tolvaptan (low blood sodium).
Miracle Fruit - More Interactions
Miracle Fruit interacts with 84 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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