Mommy's Bliss Gripe Water - Deltasone (Prednisone) Interaction
Herbal: Mommy's Bliss Gripe Water
Drug: Prednisone
Brand names:
Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, Meticorten, Sterapred, Rayos
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Mar 22, 2023
Interaction Details
Prednisone is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Mommy's Bliss Gripe Water contains fennel seed. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4. However, this has only been seen in vitro (i.e., in a lab setting) and has not been reported in humans. Additionally, the amount of fennel seed contained in Mommy's Bliss Gripe water is very low, and clinically significant interactions here are thought to be unlikely.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Pharmacist Analysis
Depending on the dose of Mommy's Bliss Gripe Water given (which depends on age), the amount of fennel seed ingested by the infant will be between 1mg and 5mg.
This small amount is very unlikely to cause a clinically significant interaction with any other drug that is metabolized via CYP3A4.
Nevertheless, the theoretical interaction is that fennel, by decreasing the activity of this enzyme, could increase the concentrations of drugs metabolized by it.
The interaction is important to be aware of but will likely not cause any issues.
References
- Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. PubMed
- Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. PubMed
Mommy's Bliss Gripe Water Overview
Mommy's Bliss Gripe Water is an over-the-counter product used to soothe colicky babies and infants. It is important to note that 'Gripe water' has been used traditionally since at least the 1800s to help treat colic and gastrointestinal discomfort in infants but 'gripe water' is not a standardized formula. Generally, it is a liquid made from a combination of water and various herbs, such as ginger, fennel, chamomile, licorice, and cinnamon, among others. Some varieties may also contain alcohol or sugar. Mommy's Bliss Gripe water contains fennel seed and ginger. It does not contain sugar or alcohol.
Prednisone Overview
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Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Prednisone is also used to treat other conditions in patients with normal corticosteroid levels. These conditions include certain types of arthritis; severe allergic reactions; multiple sclerosis (a disease in which the nerves do not function properly); lupus (a disease in which the body attacks many of its own organs); and certain conditions that affect the lungs, skin, eyes, kidneys blood, thyroid, stomach, and intestines. Prednisone is also sometimes used to treat the symptoms of certain types of cancer. Prednisone is in a class of medications called corticosteroids. It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It works to treat other conditions by reducing swelling and redness and by changing the way the immune system works.
Mommy's Bliss Gripe Water - More Interactions
Mommy's Bliss Gripe Water interacts with 786 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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