Mountain Ash - Symtuza (Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide) Interaction

Herbal: Mountain Ash
Also Known As: Sorbus aucuparia, Arbre aux Grives, Corbier d'Europe, Eberesche, Ebereschenbeeren, European Mountain-Ash, Quickbeam, Rowan, Rowan Tree, Serbal de los Cazadores, Sorb Apple, Sorbi Acupariae Fructus, Sorbier d'Europe, Sorbier des Oiseaux, Sorbier des Oiseleurs

Drug: Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide
Brand names: Symtuza

Medical Content Editor
Last updated Jul 22, 2023

Interaction Details

Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide is classified as belonging to the following category: Nephrotoxic Drugs

Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent. Theoretically, taking mountain ash berries with nephrotoxic drugs might increase the risk for kidney damage. Until more is known, advise patients to avoid taking mountain ash berries if they are taking other potentially nephrotoxic drugs.
Some potentially nephrotoxic drugs include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Mountain Ash Overview

Mountain Ash Mountain ash is a tree that belongs to the genus Sorbus. There are several different types of Mountain ash, including Sorbus aucuparia and Sorbus americana. They are native to the northern hemisphere and are known for their clusters of small, white, or pink flowers, as well as their bright red, orange, or yellow fruit. While mountain ash fruit is edible and is often used to make jams and other foods, some species of mountain ash, particularly the American mountain ash (Sorbus americana), contain hydrogen cyanide, which can be poisonous when ingested in large amounts. Additionally, mountain ash contains parasorbic acid, which can also cause harm, but cooking the fruit can change parasorbic acid into sorbic acid, which is thought to be harmless.
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Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide Overview

  • The combination of darunavir, cobicistat, emtricitabine, and tenofovir is used to treat human immunodeficiency virus (HIV) infection in adults and children weighing at least 88 pounds (40 kg) who have not been treated with other HIV medications or to replace current medication therapy in certain people already taking HIV medications. The combination of darunavir, cobicistat, emtricitabine, and tenofovir is in a class of medications called antivirals. Darunavir, emtricitabine, and tenofovir work by decreasing the amount of HIV in the blood. Cobicistat helps to keep darunavir in the body longer so that the medication will have a greater effect. Although the combination of darunavir, cobicistat, emtricitabine, and tenofovir will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting the HIV virus to other people.

See More Information Regarding Darunavir, Cobicistat, Emtricitabine, and Tenofovir

Mountain Ash - More Interactions

Mountain Ash interacts with 350 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Dr. Brian Staiger, PharmD

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Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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