Interaction Details

Methyclothiazide, Pargyline is classified as belonging to the following category: Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

Pharmacist Analysis

Although NAC has been associated with causing hypotension (low blood pressure), it appears to be relatively uncommon.

Reports of hypotension appear only to be associated when the drug has been administered IV (intravenously) for the treatment of acetaminophen overdose. Even then, it was only rarely reported (0.1% of adults) to have occurred.

The prescribing information for Mucomyst, a brand-name inhalation solution of NAC, does not list hypotension at all as a reported side effect.

Based on all the available information, the risk of clinically significant hypotension occurring when taking NAC orally as a dietary supplement is quite low, but nonetheless, remains a precaution in our drug interaction pages.

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References

  • Ruiz FJ, Salom MG, Inglés AC, et al. N-acetyl-L-cysteine potentiates depressor response to captopril and enalaprilat in SHRs. Am J Physiol. 1994;267(3 Pt 2):R767-72.

N-acetyl Cysteine (nac) Overview

N-acetyl Cysteine (nac) N-acetyl cysteine (NAC) is derived from the amino acid cysteine. It is used as a prescription medication to treat acetaminophen overdose and to help thin mucus in people with certain respiratory conditions. It is also used as a dietary supplement. NAC has a number of potential health benefits. It is a source of the antioxidant enzyme glutathione, which is important for protecting cells from oxidative stress and supporting immune function. It also may have anti-inflammatory effects and studies show it may support healthy brain function. It is generally considered safe to take NAC supplements in recommended doses.
See More Information Regarding N-acetyl Cysteine (nac)

N-acetyl Cysteine (nac) - More Interactions

N-acetyl Cysteine (nac) interacts with 288 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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