Oregano - Prometrium (Progesterone (prescription drug)) Interaction
Herbal: Oregano
Also Known As: Origanum vulgare, Carvacrol, European Oregano, Marjolaine Sauvage, Marjolaine Vivace, Mediterranean Oregano, Mountain Mint, Oil of Oregano, Oregano Oil, Organy, Origan, Origan Européen, Origani Vulgaris Herba, Origano, Winter Marjoram, Wintersweet
Drug: Progesterone (prescription drug)
Brand names:
Prometrium, Endometrin, Utrogestan
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Progesterone (prescription drug) and Oregano. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Oregano (and oregano oil) supplements are generally considered safe and there is no indication that there is an interaction between the drug highlighted in this interaction monograph and oregano.
However, as with all supplements, it is important to talk to your doctor before starting anything new, so you can be appropriately monitored.
In terms of drug interactions that have been reported with oregano, below are some examples.
Anticoagulant; Antiplatelet Drugs
Anticoagulants and antiplatelet drugs work by slowing down or preventing blood clotting. While they are essential medications for individuals with certain conditions, they come with an increased risk of bleeding.
Some studies have reported that oregano oil may also increase the risk of bleeding, as it contains compounds that have antithrombin activity and can inhibit platelet aggregation.
Therefore, taking oregano oil along with anticoagulants or antiplatelet drugs may increase the risk of bleeding, bruising, and other adverse effects.
Anti-Diabetic Drugs
Several studies suggest that oregano supplements may help lower blood glucose (i.e., sugar) levels. In vitro and animal research has shown that oregano extracts might stimulate glucose uptake and reduce blood glucose levels.
Therefore, based on the available evidence, combining oregano oil with antidiabetic drugs could potentially cause blood sugar levels to drop too low, leading to hypoglycemia.
However, it is important to note that studies reporting that oregano can reduce blood glucose levels have not reported it causing hypoglycemia.
References
- Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. PubMed
- Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. PubMed
- Antithrombin activity of some constituents from Origanum vulgare. PubMed
- Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. PubMed
Oregano Overview
Progesterone (prescription drug) Overview
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Progesterone is used as a part of hormone replacement therapy in women who have passed menopause (the change of life) and have not had a hysterectomy (surgery to remove the uterus). Hormone replacement therapy usually includes estrogen, which is used to treat symptoms of menopause and reduce the risk of developing certain diseases. However, estrogen can also cause abnormal thickening of the lining of the uterus and increase the risk of developing uterine cancer. Progesterone helps to prevent this thickening and decreases the risk of developing uterine cancer. Progesterone is also used to bring on menstruation (period) in women of childbearing age who have had normal periods and then stopped menstruating. Progesterone is in a class of medications called progestins (female hormones). It works as part of hormone replacement therapy by decreasing the amount of estrogen in the uterus. It works to bring on menstruation by replacing the natural progesterone that some women are missing.
Oregano - More Interactions
Oregano interacts with 202 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.