Oregon Grape - Opdivo (Nivolumab) Interaction
Herbal: Oregon Grape
Also Known As: Mahonia aquifolium, Barberry, Berberis, Blue Barberry, Creeping Barberry, Holly Barberry, Holly Mahonia, Holly-Leaved Berberis, Mahonia, Mahonia Faux Houx, Mahonia à Feuilles de Houx, Mahonie, Mountain-Grape, Oregon Barberry, Oregon Grape-Holly, Scraperoot
Drug: Nivolumab
Brand names:
Opdivo
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 16, 2024
Interaction Details
There were no interactions found between Nivolumab and Oregon Grape. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Oregon Grape Overview
Oregon grape (Mahonia aquifolium) is a perennial shrub that is native to the Pacific Northwest region of the United States, including Oregon and Washington. It is also found in parts of Canada. The plant is a member of the barberry family (Berberidaceae) and is closely related to the holly plant.
Oregon grape is often grown as an ornamental plant due to its attractive foliage and colorful berries. It is also used medicinally and is believed to have astringent, tonic, and anti-inflammatory properties. The root of the plant is used to make a herbal extract that is used to treat a variety of ailments, including skin conditions, digestive problems, and respiratory conditions. Most of the positive evidence for a medicinal effect is with topical applications as some research has shown topical preparations may modestly decrease the severity of psoriasis. It is important to note that the berries of the plant can be somewhat bitter and may contain toxins, so they should be eaten in moderation.
Nivolumab Overview
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Nivolumab injection is used alone or in combination with ipilimumab (Yervoy) to treat certain types of melanoma (a type of skin cancer) in adults and children 12 years of age or older that has spread to other parts of the body or cannot be removed by surgery. It is also used alone to prevent melanoma from returning after surgery. Nivolumab injection is also used in alone or in combination with ipilimumab and/or other chemotherapy medications to treat certain types of lung cancer (non-small cell lung cancer; NSCLC), renal cell cancer (a type of cancer that begins in the cells of the kidneys), Hodgkin's lymphoma (Hodgkin's disease), head and neck cancer, urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract), colorectal cancer (cancer that begins in the large intestine), hepatocellular carcinoma (HCC; a type of liver cancer), esophageal cancer (cancer of the tube that connects your throat to your stomach), gastric cancer (cancer of the stomach) or gastroesophageal junction cancer (cancer located in the area where the stomach meets the esophagus), and malignant pleural mesothelioma (a type of cancer that affects the inside lining of the lungs and chest cavity). Nivolumab is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.
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Your doctor will review your specific type of cancer and past treatment history and other available treatments to determine if nivolumab is right for you.
Oregon Grape - More Interactions
Oregon Grape interacts with 1132 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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