Para-aminobenzoic Acid (paba) - Tigecycline Interaction Details

Interaction Details

Tigecycline is classified as belonging to the following category: Sulfonamide Antibiotics

PABA inhibits the antimicrobial activity of sulfonamide antibiotics. Sulfonamide antibiotics exert antibacterial effect by competitively inhibiting folic acid synthesis from PABA. Excess PABA may overcome the folate depleting effect of the sulfonamides. Avoid using PABA concurrently with sulfonamide antibiotics. Sulfonamide antibiotics include sulfadiazine, sulfisoxazole (Gantrisin), sulfamethoxazole (Gantanol), sulfamethizole (Thiosulfil Forte), sulfasalazine (Azulfidine), and co-trimoxazole (trimethoprim-sulfamethoxazole, Bactrim, Septra).

Interaction Rating

Major

Likelihood of Occurrence

Likely

Well-controlled human studies have demonstrated the likely existence of this interaction

References

United States Pharmacopeial Convention, Inc., ed. Drug Information for the Health Care Professional. 19th ed. Englewood, CO: Micromedex Inc., 1999.

Tigecycline Overview

Tigecycline injection used to treat certain serious infections including community acquired pneumonia (a lung infection that developed in a person who was not in the hospital), skin infections, and infections of the abdomen (area between the chest and the waist). Tigecycline injection should not be used to treat pneumonia that developed in people who are on ventilators or who were in a hospital or foot infections in people who have diabetes. Tigecycline injection is in a class of medications called tetracycline antibiotics. It works by killing bacteria that cause infection.
Antibiotics such as tigecycline injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

See More Information Regarding Tigecycline Injection

Para-aminobenzoic Acid (paba) - More Interactions

Para-aminobenzoic Acid (paba) interacts with 17 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.