Perilla - Reclast (Zoledronic Acid) Interaction
Herbal: Perilla
Also Known As: Dentidia nankinensis, Ocimum frutescens, Perilla arguta, Perilla nankinensis, Perilla ocymoides, Beefsteak Plant, Huile de Pérille, Ja-So-Yeop, Japanese Basil, Japanese Melissea, Menthe Pourpre, Perilla Oil, Perilla Seed Oil, Pérille, Purple Mint, Purple Perilla, Shiso
Drug: Zoledronic Acid
Brand names:
Zometa, Aclasta, Reclast
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Zoledronic Acid and Perilla. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Perilla Overview
Perilla frutescens, an annual plant native to Asia, is valued for its diverse applications in cooking, manufacturing, and traditional medicine. Its leaves, stem, and seeds are utilized in traditional Chinese medicine for their rich content of flavones like apigenin, luteolin, shishonin, and vicenin-2, as well as beneficial compounds such as alpha-linolenic acid, rosmarinic acid, and policosanol. These components are purported to contribute to a range of health benefits, including potential anti-allergy properties that may alleviate symptoms like atopic dermatitis and airway inflammation, possibly by reducing inflammatory mediators and mast cell activity. Its anti-inflammatory effects, which may involve inhibiting cytokine production and modulating immune cell activity, align with its traditional uses for allergies, asthma, and gastrointestinal issues. Moreover, perilla is said to exhibit antimicrobial effects, with its seed extract, oil, and essential oil showing potential activity against bacteria and fungi. Laboratory research suggests potential nephroprotective effects, indicating that perilla may inhibit the proliferation of mesangial cells in kidney disorders.
Zoledronic Acid Overview
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Zoledronic acid (Reclast) is used to prevent or treat osteoporosis (condition in which the bones become thin and weak and break easily) in women who have undergone menopause ('change of life,' end of regular menstrual periods). Zoledronic acid (Reclast) is also used to treat osteoporosis in men, and to prevent or treat osteoporosis in men and women who are taking glucocorticoids (a type of corticosteroid medication that may cause osteoporosis). Zoledronic acid (Reclast) is also used to treat Paget's disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Zoledronic acid (Zometa) is used to treat high levels of calcium in the blood that may be caused by certain types of cancer. Zoledronic acid (Zometa) is also used along with cancer chemotherapy to treat bone damage caused by multiple myeloma [cancer that begins in the plasma cells (white blood cells that produce substances needed to fight infection)] or by cancer that began in another part of the body but has spread to the bones. Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer. However, it can be used to treat bone disease in patients who have cancer. Zoledronic acid is in a class of medications called bisphosphonates. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood.
Perilla - More Interactions
Perilla interacts with 0 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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