Policosanol - Corzide (Bendroflumethiazide, Nadolol) Interaction
Herbal: Policosanol
Also Known As: 32C, Dotriacontanol, Heptacosanol, Hexacosanol, Nonacosanol, Octacosanol, Tetracosanol, Tétracosanol, Tetratriacontanol, Tétratriacontanol, Triacontanol
Drug: Bendroflumethiazide, Nadolol
Brand names:
Corzide
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Bendroflumethiazide, Nadolol is classified as belonging to the following category: Beta-Blockers
Clinical research shows that policosanol 5 mg daily can have additive blood pressure-lowering effects in patients with hypertension who are taking beta-blockers. Also, animal research shows that policosanol can increase the blood-pressure lowering effects of propranolol. Theoretically, concomitant use of policosanol with beta-blockers might have additive blood pressure-lowering effects.
Some beta-blockers include atenolol (Tenormin), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), propranolol (Inderal), and others.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
- Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
Policosanol Overview
Policosanol is a supplement made from the wax of sugar cane or other sources (e.g., beeswax, rice, or wheat germ oil). It is a mixture of 24-34 carbon alcohols comprised primarily of octacosanol (28-C) but also includes tetracosanol (24-C), hexacosanol (26-C), heptacosanol (27-C), triacontanol (30-C), nonacosanol (29-C), triacosanol (30-C), dotriacontanol (32-C), docosanol, (22-C), and tetratriacontanol. It is sometimes marketed as a natural alternative to statin drugs for the treatment of high cholesterol.
Policosanol - More Interactions
Policosanol interacts with 236 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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