Pomegranate - Botox (Botulinum Toxin Type A) Interaction

Interaction Details

Pharmacist Analysis

Pomegranate (and pomegranate extract) has several potential drug interactions that should be taken into consideration.

Primarily, pomegranate can affect drugs metabolized by CYP2C9, CYP2D6, and CYP3A4 enzymes. This accounts for a very large proportion of the drug interactions associated with pomegranate.

Pomegranate also may have mild antihypertensive effects, potentially increasing the risk of adverse effects and hypotension when used with other drugs that lower blood pressure.

Although there is no interaction noted between pomegranate and the drug in question, as always, it is recommended to speak with your doctor before adding on any new medications or supplements so you can be appropraitely monitored.

Botulinum Toxin Type A Overview

• OnabotulinumtoxinA injection (Botox, Botox Cosmetic) is used to treat a number of conditions.

• OnabotulinumtoxinA injection (Botox) is used to:

  • relieve the symptoms of cervical dystonia (spasmodic torticollis; uncontrollable tightening of the neck muscles that may cause neck pain and abnormal head positions) in people 16 years of age and older;

  • relieve the symptoms of strabismus (an eye muscle problem that causes the eye to turn inward or outward) and blepharospasm (uncontrollable tightening of the eyelid muscles that may cause blinking, squinting, and abnormal eyelid movements) in adults and adolescents 12 years of age and older;

  • prevent headaches in people older than 18 years of age with chronic migraine (severe, throbbing headaches that are sometimes accompanied by nausea and sensitivity to sound or light) who have 15 or more days each month with headaches lasting 4 hours a day or longer;

  • treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination) in people 18 years of age and older when other medications do not work well enough or cannot be taken;

  • treat neurogenic detrusor overactivity (NDO; a bladder control condition caused by brain, spinal cord or nerve problem) in children 5 years of age and older when other medications did not help or could not be tolerated;

  • treat incontinence (leakage of urine) in people 18 years of age and older with overactive bladder (condition in which the bladder muscles have uncontrollable spasms) caused by nerve problems such as spinal cord injury or multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control), who cannot be treated with oral medication;

  • treat spasticity (muscle stiffness and tightness) of muscles in the arms and legs in adults and children 2 years of age and older;

  • treat severe underarm sweating in people 18 years of age and older who cannot be treated with products applied on the skin;

• and

• OnabotulinumtoxinA injection (Botox Cosmetic) is used to

  • temporarily smooth frown lines (wrinkles between the eyebrows) in adults 18 years of age and older,

  • temporarily smooth crow's feet lines (wrinkles near the outer corner of the eye) in adults 18 years of age and older,

  • and to temporarily smooth forehead lines in adults 18 years of age and older.

• OnabotulinumtoxinA injection is in a class of medications called neurotoxins. When onabotulinumtoxinA is injected into a muscle, it blocks the nerve signals that cause uncontrollable tightening and movements of the muscle. When onabotulinumtoxinA is injected into a sweat gland, it decreases the activity of the gland to reduce sweating. When onabotulinumtoxinA is injected into the bladder, it decreases bladder contractions and blocks signals that tell the nervous system that the bladder is full.

Pomegranate - More Interactions

Pomegranate interacts with 897 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.