Pregnenolone - Byfavo (Remimazolam Besylate) Interaction
Herbal: Pregnenolone
Drug: Remimazolam Besylate
Brand names:
Byfavo
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Remimazolam Besylate is classified as belonging to the following category: Benzodiazepines
Some clinical research shows that chronically administered pregnenolone decreases the sedative effects of diazepam (Valium), likely via its actions at the benzodiazepine/GABAA receptor complex.
This interaction may apply to other benzodiazepines such as lorazepam (Ativan), alprazolam (Xanax), clonazepam (Klonopin), and others.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500.
Pregnenolone Overview
Pregnenolone is a hormone that is produced naturally in the body by the adrenal glands as well as in the brain. It is a precursor to other hormones, including cortisol, progesterone, testosterone, dehydroepiandrosterone (DHEA), and estrogens, and plays a role in a number of bodily functions.
Pregnenolone is often utilized as a dietary supplement and is purported to have a number of potential health benefits, including improved memory and cognitive function, reduced anxiety and stress, and enhanced immune function. Pregnenolone is also used for its supposed anti-aging properties.
Pregnenolone - More Interactions
Pregnenolone interacts with 82 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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