Saw Palmetto - Lupron (Leuprolide acetate) Interaction
Herbal: Saw Palmetto
Also Known As: Serenoa repens, American Dwarf Palm Tree, Baies du Palmier Scie, Cabbage Palm, Chou Palmiste, Ju-Zhong, Palmier Nain, Palmier Scie, Sabal, Sabal Fructus, Saw Palmetto Berry
Drug: Leuprolide acetate
Brand names:
Lupron, Eligard, Fensolvi
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 09, 2024
Interaction Details
There were no interactions found between Leuprolide acetate and Saw Palmetto. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
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On the whole, saw palmetto has very few reported drug interactions due to its lack of effects on liver metabolizing enzymes (e.g., CYP P450 enzymes).
There have been some reports of minor interactions with anticoagulants, estrogens, and contraceptives due to saw palmetto's purported effects on blood clotting and various hormones in the body. However, these interactions have generally only been seen in lab studies and for most individuals, are not considered clinically significant.
As always, however, be sure to talk to your doctor before starting any new medications or supplements so you can be appropriately monitored.
Comprehensive analysis does not indicate a significant interaction.
- Dr. Brian Staiger, PharmDSaw Palmetto Overview
Leuprolide acetate Overview
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Leuprolide injection (Eligard, Lupron Depot) is used to treat the symptoms associated with advanced prostate cancer. Leuprolide injection (Lupron Depot-PED, Fensolvi) is used in children 2 years of age or older to treat central precocious puberty (CPP; a condition causing girls [usually younger than 8 years of age] and boys [usually younger than 9 years of age] to enter puberty too soon, resulting in faster than normal bone growth and development of sexual characteristics). Leuprolide injection (Lupron Depot) is used alone or with another medication (norethindrone) to treat endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes pain, heavy or irregular menstruation [periods], and other symptoms). Leuprolide injection (Lupron Depot) is also used with other medication to treat anemia (a lower than normal number of red blood cells) caused by uterine fibroids (noncancerous growths in the uterus). Leuprolide injection is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists. It works by decreasing the amount of certain hormones in the body.
Saw Palmetto - More Interactions
Saw Palmetto interacts with 172 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.