Saw Palmetto - Brilinta (Ticagrelor) Interaction
Herbal: Saw Palmetto
Also Known As: Serenoa repens, American Dwarf Palm Tree, Baies du Palmier Scie, Cabbage Palm, Chou Palmiste, Ju-Zhong, Palmier Nain, Palmier Scie, Sabal, Sabal Fructus, Saw Palmetto Berry
Drug: Ticagrelor
Brand names:
Brilinta
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Ticagrelor is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Pharmacist Analysis
Saw palmetto is a popular herbal supplement that has been used for various health benefits, including treating urinary symptoms associated with an enlarged prostate.
However, some research has shown that saw palmetto may increase the risk of bleeding in people taking anticoagulants or antiplatelet drugs, with the theoretical mechanism being that saw palmetto can prolonged bleeding time as a result of platelet dysfunction caused by cyclooxygenase inhibition.
This type of effect has only been reported in lab studies and limited case studies.
While more information is certainly needed to understand the effect saw palmetto has on blood coagulation, people taking anticoagulants or antiplatelet drugs should be especially cautious and avoid using saw palmetto without first consulting with their healthcare provider.
Saw palmetto is a popular herbal supplement that has been used for various health benefits, including treating urinary symptoms associated with an enlarged prostate.
However, some research has shown that saw palmetto may increase the risk of bleeding in people taking anticoagulants or antiplatelet drugs, with the theoretical mechanism being that saw palmetto can prolonged bleeding time as a result of platelet dysfunction caused by cyclooxygenase inhibition.
This type of effect has only been reported in lab studies and limited case studies.
While more information is certainly needed to understand the effect saw palmetto has on blood coagulation, people taking anticoagulants or antiplatelet drugs should be especially cautious and avoid using saw palmetto without first consulting with their healthcare provider.
- Dr. Brian Staiger, PharmDReferences
- Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9.
Saw Palmetto Overview
Ticagrelor Overview
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Ticagrelor is used to prevent a serious or life-threatening heart attack or stroke, or death in people who have had a heart attack or who have acute coronary syndrome (ACS; blockage of blood flow to the heart). It is also used to prevent blood clots from forming in people who have received coronary stents (metal tubes surgically placed in clogged blood vessels to improve blood flow) to treat ACS. Ticagrelor is used to decrease the risk of a first-time heart attack or stroke in people at risk with coronary artery disease (CAD; reduced blood flow to the heart). It is also used to decrease the risk of another more serious stroke in people who are having a mild to moderate stroke or a transient ischemic attack (TIA; ministroke). Ticagrelor is in a class of medications called antiplatelet medications. It works by preventing platelets (a type of blood cell) from collecting and forming clots that may cause a heart attack or stroke.
Saw Palmetto - More Interactions
Saw Palmetto interacts with 170 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.