Xanthan Gum - Cabozantinib S-Malate Interaction Details

Interaction Details

Cabozantinib S-Malate is classified as belonging to the following category: Oral Drugs

Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities. Xanthan gum slows gastric emptying and has been used to control the release of drugs in tablet formulations. To avoid any alterations in drug absorption, xanthan gum should be taken 30-60 minutes after oral medications.

Interaction Rating

Minor

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

Osilesi O, Trout DL, Glover EE, et al. Use of xanthan gum in dietary management of diabetes mellitus. Am J Clin Nutr 1985;42: 597-603.
Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20.

Cabozantinib S-Malate Overview

Cabozantinib (Cabometyx, Cometriq) is used to treat a number of conditions.
Cabozantinib (Cabometyx) is used:
- to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the cells of the kidneys).
- in combination with nivolumab (Opdivo) to treat advanced RCC in patients who have not yet received a treatment for RCC.
- to treat hepatocellular carcinoma (HCC; a type of liver cancer) in people who were previously treated with sorafenib (Nexafar).
- to treat a certain type of thyroid cancer in adults and children 12 years of age and older that has spread to nearby tissues or to other parts of the body and that has not responded to previous a treatment and cannot be treated with radioactive iodine.
Cabozantinib (Cometriq) is used:
- to treat a certain type of thyroid cancer that is getting worse and that has spread to other parts of the body.
Cabozantinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

See More Information Regarding Cabozantinib

Xanthan Gum - More Interactions

Xanthan Gum interacts with 1987 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.