Zizyphus - Tolvaptan Interaction
Herbal: Zizyphus
Also Known As: Ziziphus jujuba, Anèbe, Annab, Azufaifo, Badar, Ber, Black Date, Black Jujube, Chinese Date, Chinese Jujube, Da Zao, Date Seed, Datte Chinoise, Datte Noire, Fructus Jujubae, Fructus Ju Jubae, Hei Zao, Hong Zao, Jujube, Jujube Chinois, Jujube Plum, Jujube Noir, Jujube Rouge
Drug: Tolvaptan
Brand names:
Samsca, Jynarque
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 26, 2024
Interaction Details
There were no interactions found between Tolvaptan and Zizyphus. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Zizyphus Overview
Zizyphus is a genus of trees and shrubs belonging to the buckthorn family (Rhamnaceae). There are several species of Zizyphus, including Zizyphus jujuba, Zizyphus lotus, and Zizyphus mauritiana. These are all traditionally associated with common names (such as Zizyphus jujuba being known as the Chinese date or red date).
In traditional medicine, the leaves, bark, and fruit of Zizyphus species are used to treat a variety of conditions, including insomnia, anxiety, and digestive problems. Most commonly, the fruit, which is edible and resembles a date, is used. It is rich in fiber, vitamin C, B vitamins, and some fatty acids.
Tolvaptan Overview
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Tolvaptan (Jynarque) is used to slow the worsening of kidney function in certain patients with autosomal dominant polycystic kidney disease (ADPKD; a certain type of inherited kidney disease). Tolvaptan (Jynarque) is in a class of medications called vasopressin V2 receptor antagonists. It works by increasing the amount of water released from the body as urine and decreases the growth of cysts in the kidneys. Removing fluid from the body and slowing the growth of cysts helps to slow the worsening of kidney function.
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Tolvaptan is also available as a tablet (Samsca) to treat low blood levels of sodium in people who have heart failure or certain other conditions. This monograph only gives information about tolvaptan tablets (Jynarque) to slow the worsening of kidney function in patients with ADPKD. If you are using this medication to treat low levels of sodium in the blood, read the monograph entitled tolvaptan (low blood sodium).
Zizyphus - More Interactions
Zizyphus interacts with 464 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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