Acetaminophen with Lixisenatide Interaction Details
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 25, 2024
Interaction Effect
Slowed absorption of acetaminophen
Interaction Summary
Use of acetaminophen following lixisenatide administration may slow the absorption of acetaminophen due to delayed gastric emptying. While no change in acetaminophen Cmax or Tmax was observed with acetaminophen administration 1 hour before lixisenatide, acetaminophen Cmax decreased by nearly one-third and Tmax was delayed by about 2 hours with administration 1 and 4 hours after lixisenatide. If concomitant use of these agents is required, administer acetaminophen at least 1 hour before lixisenatide to avoid the delay in effect of acetaminophen[1].
Severity
Moderate
Onset
Delayed
Evidence
Probable
How To Manage Interaction
Concomitant use of acetaminophen and lixisenatide may slow the absorption of acetaminophen due to delayed gastric emptying. If concomitant use of these agents is required, administer acetaminophen at least 1 hour before lixisenatide to avoid the delay in effect of acetaminophen[1].
Mechanism Of Interaction
Delayed gastric emptying
Literature Reports
A) Administration of a single dose of acetaminophen 1000 mg before or after lixisenatide 10 mcg did change acetaminophen AUC. When acetaminophen was administered 1 hour before lixisenatide, no effects on acetaminophen Cmax and Tmax were observed; however, when administered 1 and 4 hours after lixisenatide 10 mcg, Cmax of acetaminophen was decreased by 29% and 31%, respectively, and median Tmax was delayed by 2 and 1.75 hours, respectively [1].
References
1 ) Product Information: ADLYXIN(TM) subcutaneous injection, lixisenatide subcutaneous injection. sanofi-aventis US LLC (per manufacturer), Bridgewater, NJ, 2016.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
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Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
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