Amoxicillin with Dibekacin Interaction Details

Brand Names Associated with Amoxicillin

  • Amoxicillin
  • Amoxil®
  • Amoxil® Pediatric Drops
  • Dispermox®
  • Larotid® Suspension
  • Moxtag®
  • p-Hydroxyampicillin
  • Polymox® Suspension
  • Talicia (as a combination product containing Amoxicillin, Omeprazole, Rifabutin)
  • Trimox®
  • Trimox® Pediatric Drops
  • Wymox®

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Last updated Mar 03, 2024

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Interaction Effect

Loss of aminoglycoside efficacy

Interaction Summary

Concomitant penicillin and aminoglycoside therapy has been reported to result in inactivation of the aminoglycoside both in vivo and in vitro. Amikacin appears to possess the greatest stability in the presence of penicillins; the half-life of amikacin is minimally affected by the presence of carbenicillin. It appears that, in the treatment of severely ill patients requiring both penicillin and aminoglycoside therapy, amikacin is the aminoglycoside of choice[1][2].

Severity

Minor

Onset

Rapid

Evidence

Probable

How To Manage Interaction

Monitor patients for aminoglycoside effectiveness.

Mechanism Of Interaction

Chemical inactivation of the aminoglycoside

Literature Reports

A) Although penicillins and aminoglycosides are often used in combination for their synergistic effect, a number of reports have shown that a high penicillin to aminoglycoside ratio (greater than 50:1) for a prolonged period of time results in chemical inactivation of both compounds [3][4][5][6][7][8][9][10][11][12][13]. This seems to occur in vitro when both drugs are physically mixed together, and in vivo in patients with poor renal function where renal excretion of the drugs is delayed.

References

    1 ) Farchione LA: Inactivation of aminoglycosides by penicillins. J Antimicrob Chemother 1981; 8:27-36.

    2 ) Jorgensen JH & Crawford SA: Selective inactivation of aminoglycosides by newer beta-lactam antibiotics. Curr Ther Res Clin Exp 1982; 32:25-35.

    3 ) Blair DC, Duggan DO, & Schroeder ET: Inactivation of amikacin and gentamicin by carbenicillin in patients with end-stage renal failure. Antimicrob Agents Chemother 1982; 22:376-379.

    4 ) Pickering LK & Gearhart P: effect of time and concentration upon interaction between gentamicin, tobramycin, netilmicin, or amikacin and carbenicillin or ticarcillin. Antimicrob Agents Chemother 1979; 15:592-596.

    5 ) Ervin FR, Bullock WE Jr, & Nuttall CE: Inactivation of gentamicin by penicillins in patients with renal failure. Antimicrob Agents Chemother 1976; 9:1004-1011.

    6 ) Weibert R, Keane W, & Shapiro F: Carbenicillin inactivation of aminoglycosides in patients with severe renal failure. Trans Am Soc Artif Intern Organs 1976; 22:439-443.

    7 ) Davies M, Morgan JR, & Anand C: Interactions of carbenicillin and ticarcillin with gentamicin. Antimicrob Agents Chemother 1975; 7:431-434.

    8 ) Riff L & Jackson GG: Laboratory and clinical conditions for gentamicin inactivation by carbenicillin. Arch Intern Med 1972; 130:887-891.

    9 ) Eykyn S, Phillips I, & Ridley M: Gentamicin plus carbenicillin. Lancet 1971; 1:545-546.

    10 ) McLaughlin JE & Reeves DS: Clinical and laboratory evidence for inactivation of gentamicin by carbenicillin. Lancet 1971a; 1:261-264.

    11 ) McLaughlin JE & Reeves DS: Gentamicin plus carbenicillin. Lancet 1971b; 1:864.

    12 ) Noone P & Pattison JR: Therapeutic implications of interaction of gentamicin and penicillins. Lancet 1971; 2:575-578.

    13 ) Riff L & Jackson GG: Gentamicin plus carbenicillin. Lancet 1971; 1:592.

Amoxicillin Overview

  • Amoxicillin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis (infection of the airway tubes leading to the lungs); and infections of the ears, nose, throat, urinary tract, and skin. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria.

  • Antibiotics such as amoxicillin will not work for colds, flu, and other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

See More information Regarding Amoxicillin

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Definitions

Severity Categories

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.


Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.


Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.


Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.

Onset

Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.

Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.

Evidence

Level of documentation of the interaction.

Established: The interaction is documented and substantiated in peer-reviewed medical literature.

Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.

How To Manage The Interaction

Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.

It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.

Mechanism Of Interaction

The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.

Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Where Does Our Information Come From?

Information for our drug interactions is compiled from several drug compendia, including:

The prescribing information for each drug, as published on DailyMED, is also used. 

Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.