Amoxicillin with Tigecycline Interaction Details

Brand Names Associated with Amoxicillin

Brand Names Associated with Tigecycline

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated Mar 03, 2024

Interaction Effect

Decreased antibacterial effectiveness

Interaction Summary

Bacteriostatic drugs, such as the tetracyclines, may interfere with the bactericidal effect of penicillin[1]. Such concomitant use should be avoided [2].

Severity

Major

Onset

Unspecified

Evidence

Probable

How To Manage Interaction

Avoid using tetracyclines together with penicillins due to the potential for interference of the bactericidal action of penicillins[2].

Mechanism Of Interaction

Decreased bactericidal activity

Literature Reports

A) In a review of 43 adult patients seen in one medical facility during 1950 to 1960 with a diagnosis of pneumococcal meningitis, 7 received treatment with penicillin plus a tetracycline. Of these 7 patients, 6 died (mortality of 85%). While not the only contributing factor in the clinical outcome of these patients, the antibiotic antagonism is worth noting [3].

References

1 ) Moellering RC Jr: Rationale for use of antimicrobial combinations. Am J Med 1983; 75(2A):4-8.PubMed Abstract: http://www.ncbi.nlm.nih.gov/...

2 ) Product Information: Vibramycin(R) Monohydrate oral suspension, doxycycline monohydrate oral suspension. Pfizer Labs (per FDA), New York, NY, 2013.

3 ) Olsson RA, Kirby JC, & Romansky MJ: Pneumococcal meningitis in the adult. Clinical, therapeutic, and prognostic aspects in forty-three patients. Ann Intern Med 1961; 55:545-549.PubMed Abstract: http://www.ncbi.nlm.nih.gov/...

Amoxicillin Overview

• Amoxicillin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis (infection of the airway tubes leading to the lungs); and infections of the ears, nose, throat, urinary tract, and skin. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria.

• Antibiotics such as amoxicillin will not work for colds, flu, and other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Tigecycline Overview

• Tigecycline injection used to treat certain serious infections including community acquired pneumonia (a lung infection that developed in a person who was not in the hospital), skin infections, and infections of the abdomen (area between the chest and the waist). Tigecycline injection should not be used to treat pneumonia that developed in people who are on ventilators or who were in a hospital or foot infections in people who have diabetes. Tigecycline injection is in a class of medications called tetracycline antibiotics. It works by killing bacteria that cause infection.

• Antibiotics such as tigecycline injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

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Definitions

Severity Categories

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.

Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.

Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.

Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.

Onset

Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.

Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.

Evidence

Level of documentation of the interaction.

Established: The interaction is documented and substantiated in peer-reviewed medical literature.

Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.

How To Manage The Interaction

Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.

It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.

Mechanism Of Interaction

The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.

Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Where Does Our Information Come From?

Information for our drug interactions is compiled from several drug compendia, including:

• Gold Standard Drug Database
• Micromedex
• Lexicomp
• DrugBank

The prescribing information for each drug, as published on DailyMED, is also used. 

Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.