Aspirin with Etozolin Interaction Details

Brand Names Associated with Aspirin

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated Mar 04, 2024

Interaction Effect

Reduced diuretic effectiveness and possible nephrotoxicity

Interaction Summary

Risk of renal toxicity is increased with combined use of NSAIDs and diuretics due to NSAID-associated dose-dependent reduction in prostaglandin formation and in renal blood flow. Coadministration of NSAIDs and loop diuretics has reduced the natriuretic effect of the diuretic in some patients, also related to the effect of NSAID inhibition of renal prostaglandin synthesis[1]. Increased BUN, serum creatinine, serum potassium, and weight gain have been reported with furosemide coadministered with NSAIDs. CrCl was temporarily reduced with concomitant furosemide and acetylsalicylic acid in patients with chronic renal impairment (N=6) [2]. During concomitant use of NSAIDs and diuretics, monitor for signs of worsening renal function and assure diuretic efficacy, including appropriate effects on blood pressure [3][4].

Severity

Major

Onset

Unspecified

Evidence

Probable

How To Manage Interaction

Risk of renal toxicity is increased with combined use of NSAIDs and diuretics, and use of NSAIDs with loop diuretics has reduced the natriuretic effect of the diuretic in some patients. During concomitant use of NSAIDs and diuretics, monitor for signs of worsening renal function and assure diuretic efficacy, including appropriate effects on blood pressure[1][3][4].

Mechanism Of Interaction

Decreased renal prostaglandin synthesis

Literature Reports

A) In part A of a study designed to investigate the influence of diuretics on renal prostaglandins, 24 healthy subjects on a constant sodium intake received furosemide (80 mg daily), hydroCHLOROthiazide (100 mg), triamterene (200 mg), or spironolactone (300 mg). In part B of the study, the same subjects were pretreated for 3 days with indomethacin (150 mg daily). This was continued during the 3-day administration of the diuretics. In study A, triamterene administration led to a rise in urinary prostaglandins E2 and F2 alpha, but this was not observed with the other diuretics. In study B, the natriuretic effect of spironolactone and furosemide was reduced and was unaffected by hydroCHLOROthiazide and triamterene. Prostaglandins were significantly inhibited in all subjects. The results suggest that prostaglandins contribute to the interaction between NSAIDs and the natriuretic effects of furosemide and spironolactone, but not to the natriuretic effects of hydroCHLOROthiazide and triamterene [5].

B) A base cohort study involving 10,519 patients older than 55 years who were receiving NSAIDs and diuretics was conducted to investigate the relationship between congestive heart failure (CHF) and the use of these 2 classes of drugs. The patient population was 72.2% female, with an average age of 70.8 years. During periods of concomitant NSAID and diuretic use, the risk of hospitalization for CHF was twice that of periods of diuretic use only. Patients who used diuretics on a regular basis also had an increased risk of hospitalization due to CHF compared with irregular users of diuretics. A combination of a thiazide and a potassium-sparing diuretic was the most frequently used diuretic type, and the incidence density of hospitalizations during times of use with this combination and a NSAID resulted in a 3-fold increase over that for diuretic use only [6].

C) Concomitant therapy with oral furosemide 40 mg daily and oral azapropazone 1200 mg daily demonstrated that the hypouricemic effect of azapropazone was only slightly antagonized by furosemide; the diuretic effect of furosemide was not altered significantly [7].

References

1 ) Product Information: DAYPRO(R) oral caplets, oxaprozin oral caplets. GD Searle LLC (per FDA), New York, NY, 2016.

2 ) Product Information: LASIX(R) oral tablets, furosemide oral tablets. sanofi-aventis U.S. LLC (per FDA), Bridgewater, NJ, 2016.

3 ) Product Information: ANAPROX(R) oral tablets, naproxen sodium oral tablets. Canton Laboratories, LLC (per FDA), Alpharetta, GA, 2016.

4 ) Product Information: CALDOLOR(R) intravenous injection, ibuprofen intravenous injection. Cumberland Pharmaceuticals Inc. (per FDA), Nashville, TN, 2016.

5 ) Favre L, Glasson P, Riondel A, et al: Interaction of diuretics and non-steroidal anti-inflammatory drugs in man. Clin Sci (Lond) 1983; 64(4):407-415.

6 ) Heerdink ER, Leufkens HG, Herings RMC, et al: NSAIDs associated with increased risk of congestive heart failure in elderly patients taking diuretics. Arch Intern Med 1998; 158:1108-1112.

7 ) Williamson P, Ene M, & Roberts C: A study of the potential interactions between azapropazone and frusemide in man. Br J Clin Pharmacol 1984; 18:619-623.

Aspirin Overview

• Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots.

• Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information.

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Definitions

Severity Categories

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.

Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.

Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.

Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.

Onset

Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.

Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.

Evidence

Level of documentation of the interaction.

Established: The interaction is documented and substantiated in peer-reviewed medical literature.

Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.

How To Manage The Interaction

Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.

It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.

Mechanism Of Interaction

The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.

Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Where Does Our Information Come From?

Information for our drug interactions is compiled from several drug compendia, including:

• Gold Standard Drug Database
• Micromedex
• Lexicomp
• DrugBank

The prescribing information for each drug, as published on DailyMED, is also used. 

Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.