Aspirin and Reteplase, Recombinant: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Aspirin
Reteplase, Recombinant
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of bleeding
Interaction Deep Dive
Concurrent administration of aspirin and reteplase may produce enhanced anticoagulation, leading to an increased risk of internal and superficial hemorrhage. Heparin and aspirin have been administered concurrently with and following the administration of reteplase in the management of acute myocardial infarction. In all three studies evaluating the safety and efficacy of reteplase, patients were treated with aspirin (initial doses of 160 mg to 350 mg and subsequent doses of 75 mg to 350 mg) and heparin (a 5,000 unit intravenous bolus prior to the administration of reteplase, followed by a 1000 unit/hour continuous infusion for at least 24 hours). Because heparin, aspirin, or reteplase may cause bleeding complications, careful monitoring for bleeding is advised, especially at arterial puncture sites1.
Why it happens (mechanism)
Additive anticoagulation effects
Common questions
Can I take Aspirin and Reteplase, Recombinant together?
An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Aspirin and Reteplase, Recombinant interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Aspirin or Reteplase, Recombinant need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Retavase(TM), reteplase, recombinant. Boehringer Mannheim Corporation, Therapeutics Division, Gaithersburg, MD, 1996.
Keep reading about Aspirin
Keep reading about Reteplase, Recombinant
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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