Atomoxetine with Lorcaserin Interaction Details

Brand Names Associated with Atomoxetine

  • Atomoxetine
  • Strattera®

Brand Names Associated with Lorcaserin

  • Belviq®
  • Belviq® XR
  • Lorcaserin

Medical Content Editor
Last updated Mar 04, 2024

Curious for more information about this interaction?

Ask our pharmacists directly!

Reach out to us

Interaction Effect

Increased atomoxetine plasma concentrations

Interaction Summary

The concomitant use of atomoxetine, a CYP2D6 substrate[1], and lorcaserin, a CYP2D6 inhibitor, may increase atomoxetine plasma concentrations and should be approached with caution [2]. Dose reduction of atomoxetine may be required when coadministered with lorcaserin [1].

Severity

Moderate

Onset

Unspecified

Evidence

Theoretical

How To Manage Interaction

Use caution with the concomitant use of atomoxetine with lorcaserin as coadministration may cause increased atomoxetine plasma concentrations[2]. If concomitant use is required, dose reduction may be warranted for atomoxetine [1].

Mechanism Of Interaction

Inhibition of CYP2D6-mediated atomoxetine metabolism by lorcaserin

References

    1 ) Product Information: STRATTERA(R) oral capsules, atomoxetine HCl oral capsules. Eli Lilly and Company (per FDA), Indianapolis, IN, 2012.

    2 ) Product Information: BELVIQ(R) oral tablets, lorcaserin hydrochloride oral tablets. Eisai Inc. (per manufacturer), Woodcliff Lake, NJ, 2012.

Atomoxetine Overview

  • Atomoxetine is used as part of a total treatment program to increase the ability to pay attention and decrease impulsiveness and hyperactivity in children and adults with ADHD. Atomoxetine is in a class of medications called selective norepinephrine reuptake inhibitors. It works by increasing the levels of norepinephrine, a natural substance in the brain that is needed to control behavior.

See More information Regarding Atomoxetine

Lorcaserin Overview

  • Lorcaserin is used to help adults who are obese or who are overweight and have weight-related medical problems to lose weight and keep from gaining back that weight. Lorcaserin must be used along with a reduced calorie diet and an exercise plan. Lorcaserin is in a class of medications called serotonin receptor agonists. It works by increasing feelings of fullness so that less food is eaten.

See More information Regarding Lorcaserin

Return To Our Drug Interaction Homepage

Feedback, Question Or Comment About This Information?

Ask , our medical editor, directly! He's always more than happy to assist.

Definitions

Severity Categories

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.


Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.


Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.


Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.

Onset

Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.

Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.

Evidence

Level of documentation of the interaction.

Established: The interaction is documented and substantiated in peer-reviewed medical literature.

Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.

How To Manage The Interaction

Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.

It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.

Mechanism Of Interaction

The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.

Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Where Does Our Information Come From?

Information for our drug interactions is compiled from several drug compendia, including:

The prescribing information for each drug, as published on DailyMED, is also used. 

Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.