Carisoprodol with Quetiapine Interaction Details
Brand Names Associated with Carisoprodol
- Carisoprodol
- Rela®
- Soma Compound with Codeine® (as a combination product containing Aspirin, Carisoprodol, Codeine)
- Soma Compound® (as a combination product containing Aspirin, Carisoprodol)
- Soma®
Brand Names Associated with Quetiapine
- Quetiapine
- Seroquel®
- Seroquel® XR
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Dec 31, 2023
Interaction Effect
An increased risk of anticholinergic side effects, including intestinal obstruction
Interaction Summary
Norquetiapine, an active metabolite of quetiapine, has moderate to strong affinity for several muscarinic receptor subtypes, which contributes to the anticholinergic adverse reactions when quetiapine is used concomitantly with other anticholinergic medications. Concomitant use with anticholinergic agents increases the risk for severe gastrointestinal adverse reactions related to hypomotility. Fatalities due to intestinal obstruction have been reported. Quetiapine should be used with caution in patients receiving other anticholinergic (antimuscarinic) agents. Concomitant administration of glycopyrrolate and other anticholinergics like quetiapine may increase the risk of additive anticholinergic effects .
Severity
Major
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
Norquetiapine, an active metabolite of quetiapine, has moderate to strong affinity for several muscarinic receptor subtypes, which contributes to the anticholinergic adverse reactions when quetiapine is used concomitantly with other anticholinergic medications. Concomitant use with anticholinergic agents increases the risk for severe gastrointestinal adverse reactions related to hypomotility. Fatalities due to intestinal obstruction have been reported. Quetiapine should be used with caution in patients receiving other anticholinergic (antimuscarinic) agents. Concomitant administration of glycopyrrolate and other anticholinergics like quetiapine may increase the risk of additive anticholinergic effects .
Mechanism Of Interaction
Additive anticholinergic effects caused by norquetiapine, an active metabolite of quetiapine
Literature Reports
A) Intestinal obstruction, including fatalities has been reported with the concomitant use of quetiapine and multiple concomitant medications that decrease intestinal motility .
Carisoprodol Overview
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Carisoprodol is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Carisoprodol is in a class of medications called skeletal muscle relaxants. It works by acting in the brain and nervous system to allow the muscles to relax.
Quetiapine Overview
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Quetiapine tablets and extended-release (long-acting) tablets are used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Quetiapine tablets and extended-release tablets are also used alone or with other medications to treat episodes of mania (frenzied, abnormally excited or irritated mood) or depression in patients with bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). In addition, quetiapine tablets and extended-release tablets are used with other medications to prevent episodes of mania or depression in patients with bipolar disorder. Quetiapine extended-release tablets are also used along with other medications to treat depression. Quetiapine tablets may be used as part of a treatment program to treat bipolar disorder and schizophrenia in children and teenagers. Quetiapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.