Diazepam

40 interactions 5 explained in plain English
Also sold as: Diastat Libervant Valium Valtoco
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Diazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Diazepam Abametapir Explained Increased exposure of CYP3A4 substrate Details Diazepam Omeprazole Gastrobim Explained Increased diazepam exposure Details Diazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Diazepam Aripiprazole Injection Abilify Increased risk of CNS depression and orthostatic hypotension Details Diazepam Asenapine Transdermal Patch Secuado Increased risk of CNS depression Details Diazepam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Diazepam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Diazepam Calcifediol Rayaldee Altered serum levels of calcifediol Details Diazepam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Diazepam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Diazepam Diphenhydramine Injection Banophen Increased risk of CNS depression Details Diazepam Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression Details Diazepam Esketamine Nasal Spray Spravato Increased risk of sedation Details Diazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Diazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Diazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Diazepam Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Diazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Diazepam Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Diazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Diazepam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Diazepam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Diazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Diazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Diazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Diazepam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Diazepam Orlistat Alli Reduced efficacy of anticonvulsant Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.