Diazepam
40 interactions 5 explained in plain English
Also sold as:
Diastat
Libervant
Valium
Valtoco
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Diphenhydramine Injection
Abametapir
Omeprazole
Buprenorphine
Orlistat
Fentanyl Transdermal Patch
Major
Diazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Diazepam Abametapir Explained Increased exposure of CYP3A4 substrate Details Diazepam Omeprazole Gastrobim Explained Increased diazepam exposure Details Diazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Diazepam Aripiprazole Injection Abilify Increased risk of CNS depression and orthostatic hypotension Details Diazepam Asenapine Transdermal Patch Secuado Increased risk of CNS depression Details Diazepam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Diazepam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Diazepam Calcifediol Rayaldee Altered serum levels of calcifediol Details Diazepam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Diazepam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Diazepam Diphenhydramine Injection Banophen Increased risk of CNS depression Details Diazepam Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression Details Diazepam Esketamine Nasal Spray Spravato Increased risk of sedation Details Diazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Diazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Diazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Diazepam Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Diazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Diazepam Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Diazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Diazepam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Diazepam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Diazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Diazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Diazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Diazepam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Diazepam Orlistat Alli Reduced efficacy of anticonvulsant DetailsModerate
Diazepam Amitriptyline Elavil Explained Psychomotor deficits (decreased reaction time, decreased vigilance) Details Diazepam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Diazepam Digoxin Cardoxin® Digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Diazepam Disulfiram Antabuse An increased risk of central nervous system depression Details Diazepam Esomeprazole Nexium Increased exposure of diazepam Details Diazepam Esomeprazole Injection Nexium Increased exposure of diazepam Details Diazepam Estradiol Delestrogen Diazepam toxicity (CNS depression, hypotension) Details Diazepam Estradiol Topical Divigel Diazepam toxicity (CNS depression, hypotension) Details Diazepam Estradiol Transdermal Patch Alora® Diazepam toxicity (CNS depression, hypotension) Details Diazepam Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Diazepam Levonorgestrel After banger Diazepam toxicity (CNS depression, hypotension) Details Diazepam Levonorgestrel Intrauterine System Kyleena Diazepam toxicity (CNS depression, hypotension) DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.