Empagliflozin

104 interactions 237 cited references

Also sold as: Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Jardiance Jardiance® Synjardy® (as a combination product containing Empagliflozin and Metformin)

About Empagliflozin

An SGLT2 inhibitor used to lower blood sugar in type 2 diabetes and reduce heart disease risk. Read the full Empagliflozin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Gatifloxacin Ophthalmic Insulin Detemir (Rdna Origin) Injection Furosemide Injection Octreotide Injection Abiraterone Acetate Abiraterone Acetate, Micronized

58 Major 46 Moderate

All (104) Major (58) Moderate (46)

Major

Empagliflozin Abiraterone Abirtega An increased risk of severe hypoglycemia Details Empagliflozin Chloroquine Aralen® Hypoglycemia Details Empagliflozin Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Abiraterone Acetate Abirtega An increased risk of severe hypoglycemia Details Empagliflozin Abiraterone Acetate, Micronized Abirtega An increased risk of severe hypoglycemia Details Empagliflozin Chlorothiazide Diuril An increased risk of hyperglycemia and an increased insulin requirement Details Empagliflozin Chlorthalidone Hemiclor An increased risk of hyperglycemia and an increased insulin requirement Details Empagliflozin Ciprofloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Enoxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Furosemide Disal An increased risk of hyperglycemia and an increased insulin requirement Details Empagliflozin Gatifloxacin Zymaxid Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Grepafloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Hydrochlorothiazide Inzirqo An increased risk of hyperglycemia and an increased insulin requirement Details Empagliflozin Hydroflumethiazide An increased risk of hyperglycemia and an increased insulin requirement Details Empagliflozin Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Empagliflozin Indapamide An increased risk of hyperglycemia and an increased insulin requirement Details Empagliflozin Insulin Afrezza An increased risk of hypoglycemia Details Empagliflozin Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Empagliflozin Insulin Bovine An increased risk of hypoglycemia Details Empagliflozin Insulin Degludec Tresiba An increased risk of hypoglycemia Details Empagliflozin Insulin Detemir Levemir An increased risk of hypoglycemia Details Empagliflozin Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Empagliflozin Insulin Glulisine Apidra An increased risk of hypoglycemia Details Empagliflozin Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Empagliflozin Insulin Lispro, Recombinant Admelog An increased risk of hypoglycemia Details Empagliflozin Lanreotide Acetate An increased risk of hypoglycemia and impaired glucose regulation Details Empagliflozin Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Lithium Reduced lithium exposure Details Empagliflozin Lomefloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Metolazone An increased risk of hyperglycemia and an increased insulin requirement Details Empagliflozin Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Norfloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Octreotide Acetate An increased risk of hypoglycemia and impaired glucose regulation Details Empagliflozin Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Empagliflozin Pasireotide Diaspartate An increased risk of hypoglycemia and impaired glucose regulation Details Empagliflozin Polythiazide An increased risk of hyperglycemia and an increased insulin requirement Details Empagliflozin Pramlintide Symlin An increased risk of hypoglycemia Details Empagliflozin Somatrogon-Ghla Reduced insulin sensitivity Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.