Ethinyl Estradiol; Norethindrone with Tipranavir Interaction Details
Brand Names Associated with Tipranavir
- Aptivus®
- Tipranavir
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 12, 2023
Interaction Effect
Decreased estrogen concentration and increased risk of developing a non-serious rash
Interaction Summary
In pharmacokinetic studies, a single dose of 0.035 milligrams (mg) of ethinyl estradiol coadministered with tipranavir, in combination with ritonavir, dosed as tipranavir/ritonavir 500/100 mg (n=21), 750/200 mg (n=13) twice daily resulted in decreased ethinyl estradiol maximum serum concentrations (Cmax) and area under the concentration-time curve (AUC) by approximately 50%. Alternative methods of nonhormonal contraception should be considered when estrogen-based oral contraceptives are administered concurrently with tipranavir and 200 milligrams of ritonavir. Patients using estrogens as hormone replacement therapy should be monitored for signs of estrogen deficiency. Additionally, there may be an increased risk of developing a non-serious rash when tipranavir is coadministered with estrogens.
Severity
Moderate
Onset
Unspecified
Evidence
Established
How To Manage Interaction
Concurrent administration of ethinyl estradiol with tipranavir and ritonavir results in decreased concentrations of ethinyl estradiol. Consider using alternative methods of nonhormonal contraception when estrogen-based oral contraceptives are administered concurrently with tipranavir and 200 milligrams of ritonavir. Additionally, monitor patients using estrogens as hormone replacement therapy for signs of estrogen deficiency. There may be an increased risk of developing a non-serious rash when tipranavir is coadministered with estrogens.
Mechanism Of Interaction
Unknown
Tipranavir Overview
-
Tipranavir is used with ritonavir (Norvir) and other medications to treat human immunodeficiency virus infection (HIV). Tipranavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although tipranavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.