Infliximab Interactions

Infliximab injection products are used to relieve the symptoms of certain autoimmune disorders (conditions in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage) including:

  • rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that is also being treated with methotrexate (Rheumatrex, Trexall),

  • Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) in adults and children 6 years of age or older that has not improved when treated with other medications,

  • ulcerative colitis (condition that causes swelling and sores in the lining of the large intestine) in adults and children 6 years of age or older that has not improved when treated with other medications,

  • ankylosing spondylitis (a condition in which the body attacks the joints of the spine and other areas causing pain and joint damage),

  • plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults when other treatments are less appropriate,

  • and psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin).

Infliximab injection products are in a class of medications called tumor necrosis factor-alpha (TNF-alpha) inhibitors. They work by blocking the action of TNF-alpha, a substance in the body that causes inflammation.

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Brand Names Associated with Infliximab

  • Anti-TNF-alpha
  • Anti-tumor Necrosis Factor-alpha
  • Avsola® (Infliximab-axxq)
  • cA2
  • Inflectra® (Infliximab-dyyb)
  • Infliximab Injection
  • Remicade® (Infliximab)
  • Renflexis® (Infliximab-abda)

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The drugs below are categorized by the severity of their interaction (see description of categories at the bottom of the page).

Click the drug name (listed by the generic name) to view specific drug-drug interaction details.
Navigate: Major | Moderate

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What Do The Severity Ratings Mean?

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.


Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.


Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.


Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.

Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Drug interaction information is compilated from several drug compendia, including:

  • Gold Standard Drug Database
  • Micromedix
  • Lexicomp
  • PubMed

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.